Repeatedly positive human immunodeficiency virus type 1 DNA polymerase chain reaction in human immunodeficiency virus-exposed seroreverting infants
| Autor: | Saroj S. Bakshi, Savita Pahwa, M. Paul, Surya Tetali, Elaine J. Abrams |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Microbiology (medical)
Male DNA polymerase Remission Spontaneous CD4-CD8 Ratio HIV Core Protein p24 Enzyme-Linked Immunosorbent Assay Polymerase Chain Reaction Virus law.invention Cohort Studies Immune system Acquired immunodeficiency syndrome (AIDS) law HIV Seropositivity medicine Humans Sida Polymerase chain reaction biology Viral culture business.industry Infant Newborn virus diseases Infant biology.organism_classification medicine.disease Virology Infectious Disease Transmission Vertical Infectious Diseases Pediatrics Perinatology and Child Health Immunology DNA Viral biology.protein HIV-1 Female Viral disease business Follow-Up Studies |
| Zdroj: | The Pediatric infectious disease journal. 14(8) |
| ISSN: | 0891-3668 |
| Popis: | Three human immunodeficiency virus type 1 (HIV-1)-exposed children who had repeatedly positive DNA polymerase chain reaction (PCR) tests for HIV in > or = 5 samples before seroreversion to HIV-negative status are reported. The children belong to a cohort of 210 infants who were born to HIV-infected mothers and were tested at intervals of 1 to 3 months by HIV viral culture, PCR, and p24 antigen; only the PCR was positive in > or = 5 samples in the children reported here. Their clinical features were indistinguishable from other seroreverters. All three children had a transient drop in CD4:CD8 ratio to < 1.0. The transiently positive DNA PCR in HIV-exposed infants may indicate either that HIV infection was eliminated by a strong host immune response or that infection was caused by an attenuated/defective strain of virus. |
| Databáze: | OpenAIRE |
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