Matriptase and Survivin Expression Associated with Tumor Progression and Malignant Potential in Breast Cancer of Chinese Women: Tissue Microarray Analysis of Immunostaining Scores with Clinicopathological Parameters

Autor: Lai-Fa Sheu, Hung Chiang, Wen-Chiuan Tsai, Cheng-Pin Yu, Jong-Shiaw Jin, Chi-Hong Chu, Ann Chen
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Oncology
Pathology
Survivin
Clinical Biochemistry
Atypical ductal hyperplasia
matriptase
Inhibitor of Apoptosis Proteins
ductal carcinoma in situ
skin and connective tissue diseases
Aged
80 and over
lcsh:R5-920
Tissue microarray
biology
Carcinoma
Ductal
Breast
Serine Endopeptidases
General Medicine
Middle Aged
Immunohistochemistry
Neoplasm Proteins
Disease Progression
Female
Breast carcinoma
lcsh:Medicine (General)
Microtubule-Associated Proteins
Adult
medicine.medical_specialty
Breast Neoplasms
Breast cancer
Internal medicine
Genetics
medicine
Carcinoma
invasive ductal carcinoma
Humans
Matriptase
Molecular Biology
neoplasms
Aged
Neoplasm Staging
business.industry
Biochemistry (medical)
Ductal carcinoma
medicine.disease
Fibroadenoma
body regions
Tumor progression
Tissue Array Analysis
biology.protein
Other
business
Zdroj: Disease Markers, Vol 24, Iss 2, Pp 89-99 (2008)
Disease markers
ISSN: 1875-8630
0278-0240
Popis: Objective: The aim of this study was to examine the expression of matriptase and survivin in breast carcinoma and correlate with clinicopathological parameters.Methods: Immunohistochemical analysis of matriptase and survivin were performed in tissue microarray slides of 290 cases, including 11 normal breast tissue; 27 fibrocystic disease; 17 fibroadenoma; 6 atypical ductal hyperplasia; 39 ductal carcinoma in situ, low grade (DCIS, low grade); 39 ductal carcinoma in situ, high grade (DCIS, high grade); 27 invasive ductal carcinoma, grade I (IDC, grade I); 78 invasive ductal carcinoma, grade II (IDC, grade II); and 46 invasive ductal carcinoma, grade III (IDC, grade III).Results: The average immunostaining scores of matriptase were 44.1 in normal breast tissue, 52.7 in fibrocystic disease, 76.5 in fibroadenoma, 81.7 in atypical ductal hyperplasia, 133.7 in low-grade DCIS, and 155.8 in high-grade DCIS. Among 151 breast IDC cases, the average immunostaining scores of matriptase were 172.7 in grade I, 211.7 in grade II, and 221.2 in grade III. Additionally, the average immunostaining scores of surviving also correlate with tumor grades and stages.Conclusions: Higher expressions of matriptase and survivin correlate significantly with clinicopathological parameters in breast cancer and the malignant potential in premalignant lesions. In addition, higher survivin expression had poorer prognosis of breast IDC cases.
Databáze: OpenAIRE
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