Predisposition to Cervical Atypia in Systemic Lupus Erythematosus: A Clinical and Cytopathological Study
| Autor: | Hend Hilal Al-Sherbeni, Ahmed Fahmy, Nadine Sherif |
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| Rok vydání: | 2015 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Cervical cancer medicine.medical_specialty Pathology Article Subject medicine.diagnostic_test business.industry Immunology Physical examination Disease Cervical Atypia medicine.disease Dermatology Cervical Change Abnormal PAP Smear Immunology and Microbiology (miscellaneous) immune system diseases Dysplasia medicine Immunology and Allergy Medical history lcsh:RC581-607 skin and connective tissue diseases business Research Article |
| Zdroj: | Autoimmune Diseases Autoimmune Diseases, Vol 2015 (2015) |
| ISSN: | 2090-0430 2090-0422 |
| DOI: | 10.1155/2015/751853 |
| Popis: | Introduction. Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course, and prognosis. The female genital tract may be a potential target organ in SLE since cervical inflammation may be associated with disease activity. An increase in cervical dysplasia, a precursor of cervical cancer, has been reported in females with SLE.Aim of the Work. This work aimed to study the prevalence of abnormal cervicovaginal smears in patients with systemic lupus erythematosus (SLE) and to correlate abnormal smear findings with exposure to infection with human papilloma virus (HPV) in SLE patients.Patients and Methods. Thirty-two patients with SLE, fulfilling the 1997 revised criteria for the classification of SLE, were included in this study. They were subjected to full history taking, clinical examination, laboratory investigations, and cervicovaginal smearing. Twenty healthy subjects not known to suffer from any rheumatological disease were used as controls, and they were subjected to cervicovaginal smearing.Results. Four out of 32 SLE patients showed abnormal Pap smears (12.5%) compared to none showing any cervical changes in the control group (0%). Among these 4 patients, 3 were having ASCU and one was having LSIL (HPV).Conclusion. Cervicovaginal smearing is an easy, economic, safe, repeatable, and noninvasive technique for screening and early detection of cervical neoplastic lesions in SLE. |
| Databáze: | OpenAIRE |
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