Tumor texture parameters of invasive ductal breast carcinoma in neoadjuvant chemotherapy: early identification of non-responders on breast MRI
| Autor: | Zorica Milosevic, Mirjan Nadrljanski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_treatment Breast Neoplasms 030218 nuclear medicine & medical imaging Objective assessment 03 medical and health sciences 0302 clinical medicine Medicine Breast MRI Humans Radiology Nuclear Medicine and imaging In patient Invasive Ductal Breast Carcinoma Aged Retrospective Studies Chemotherapy Tumor size medicine.diagnostic_test business.industry Middle Aged Magnetic Resonance Imaging Neoadjuvant Therapy Carcinoma Ductal Radiography Non responders Treatment Outcome 030220 oncology & carcinogenesis Kurtosis Female business Nuclear medicine |
| Zdroj: | Clinical imaging. 65 |
| ISSN: | 1873-4499 |
| Popis: | Purpose Texture analysis (TA) parameters (variance of SI, mean of gradient, variance of gradient, kurtosis of SI, and entropy) in patients with invasive ductal carcinoma (IDC) contribute to objective assessment of neoadjuvant chemotherapy (NACT) activity. The objective was to assess TA parameters in early identification of non-responders (NR) in NACT, after the 2nd cycle of NACT. Material and methods Fifty patients (N = 50) were included in the retrospective analysis of baseline and MRI following the 2nd cycle of NACT. TA parameters were computed and correlated to the lesion size and DWI-ADC in NR (N1 = 25). Additional matched responders (R, N2 = 25) assessed for the same parameters, served as the control group. Results Tumor size and ADC did not change significantly in NR after the 2nd cycle of NACT (2.88 ± 0.38 vs. 2.76 ± 0.36 [cm], p = 0.131; 1.01 ± 0.14 vs. 1.05 ± 0.13 [mm2/s × 10−3], p = 0.363), but TA parameters changed significantly: variance of gradient (346.5 ± 12.6 vs. 355.6 ± 16.9, p = 0.01), kurtosis of SI (1.47 ± 0.09 vs. 1.54 ± 0.11, p = 0.02), entropy LH (60.39 ± 4.34 vs. 64.42 ± 3.05, p = 0.001) and entropy HL (61.02 ± 5.51 vs. 65.63 ± 3.63, p Conclusion Entropy, kurtosis of SI and variance of gradient tend to increase in NR. TA parameters significantly differ between NR and R after the 2nd cycle of NACT. TA parameters, related to morpho-functional parameters may contribute to early NR identification. |
| Databáze: | OpenAIRE |
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