Maturational trajectories of pericortical contrast in typical brain development
| Autor: | Alan C. Evans, Olivier Parent, Sherif Karama, Aurélie Labbe, Stefan Drakulich, M. Mallar Chakravarty, Matthew D. Albaugh, Budhachandra Khundrakpam, Anne-Charlotte Thiffault, Simon Ducharme, Emily Olafson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Brain development Adolescent Cognitive Neuroscience Human Development Neurosciences. Biological psychiatry. Neuropsychiatry Biology 050105 experimental psychology Article 03 medical and health sciences Young Adult 0302 clinical medicine Sex Factors Humans 0501 psychology and cognitive sciences Longitudinal Studies Gray Matter Child Cerebral Cortex 05 social sciences Contrast (statistics) Cortical contrast Magnetic Resonance Imaging White Matter Childhood Adolescence Structural MRI Neurology Child Preschool Female Akaike information criterion Gray-white contrast Cartography 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | NeuroImage, Vol 235, Iss, Pp 117974-(2021) NeuroImage |
| ISSN: | 1095-9572 |
| Popis: | In the last few years, a significant amount of work has aimed to characterize maturational trajectories of cortical development. The role of pericortical microstructure putatively characterized as the gray-white matter contrast (GWC) at the pericortical gray-white matter boundary and its relationship to more traditional morphological measures of cortical morphometry has emerged as a means to examine finer grained neuroanatomical underpinnings of cortical changes. In this work, we characterize the GWC developmental trajectories in a representative sample (n = 394) of children and adolescents (~4 to ~22 years of age), with repeated scans (1–3 scans per subject, total scans n = 819). We tested whether linear, quadratic, or cubic trajectories of contrast development best described changes in GWC. A best-fit model was identified vertex-wise across the whole cortex via the Akaike Information Criterion (AIC). GWC across nearly the whole brain was found to significantly change with age. Cubic trajectories were likeliest for 63% of vertices, quadratic trajectories were likeliest for 20% of vertices, and linear trajectories were likeliest for 16% of vertices. A main effect of sex was observed in some regions, where males had a higher GWC than females. However, no sex by age interactions were found on GWC. In summary, our results suggest a progressive decrease in GWC at the pericortical boundary throughout childhood and adolescence. This work contributes to efforts seeking to characterize typical, healthy brain development and, by extension, can help elucidate aberrant developmental trajectories. |
| Databáze: | OpenAIRE |
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