A new immunostimulatory complex (PICKCa) in experimental rabies: antiviral and adjuvant effects
| Autor: | H X Lin, C Gontier, M F Saron, Pierre Perrin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Interleukin 2
Male medicine.medical_specialty Time Factors Rabies medicine.medical_treatment Antibodies Viral Lymphocyte Activation Cell Line Mice Immune system Rabies vaccine Medical microbiology Adjuvants Immunologic Interferon Neutralization Tests Virology medicine Aluminum Oxide Animals Mice Inbred C3H biology General Medicine T-Lymphocytes Helper-Inducer medicine.disease Poly I-C Immunoglobulin M Rabies Vaccines Immunoglobulin G Immunology biology.protein Interleukin-2 Female Interferons Antibody Adjuvant medicine.drug ISCOMs |
| Zdroj: | Archives of virology. 131(3-4) |
| ISSN: | 0304-8608 |
| Popis: | The activity of an immunostimulatory complex (PICKCa) which is widely used against several human diseases in China was tested in experimental rabies prophylaxis. PICKCa protected mice against peripheral infection with both fixed and wild rabies strains. It also enhanced the protective activity of an experimental rabies vaccine injected either before or after rabies infection. PICKCa enhanced both non-specific immune responses and specific immunity including antibody production and cell mediated immunity as assessed by interleukin-2 production. |
| Databáze: | OpenAIRE |
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