Klotho dysfunction: A pathway linking the aging process to bipolar disorder?
| Autor: | Izabela Guimarães Barbosa, Gokay Alpak, Rodrigo Barreto Huguet, Fábio Lopes Rocha, Antônio Lúcio Teixeira, Natalia Pessoa Rocha, Érica Leandro Marciano Vieira, Breno S. Diniz |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Premature aging Aging medicine.medical_specialty Bipolar Disorder Inflammation Comorbidity urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Hypothyroidism Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Bipolar disorder Klotho Proteins Klotho Biological Psychiatry Glucuronidase Significant difference Middle Aged medicine.disease female genital diseases and pregnancy complications 030227 psychiatry Psychiatry and Mental health Endocrinology Mood disorders Hypertension Disease Progression Female medicine.symptom Psychology Mania 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychiatric Research. 95:80-83 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2017.08.007 |
| Popis: | Aim Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls. Methods Forty patients with type 1 BD and 30 controls were enrolled in this study. After clinical evaluation, peripheral blood samples were drawn and plasma levels of Klotho were measured using enzyme-linked immunosorbent assay. Results Patients with BD and controls presented similar age and sex distribution. The mean ± SD length of illness was 24.00 ± 12.75 years. BD patients presented increased frequency of clinical comorbidities in comparison with controls, mainly arterial hypertension, diabetes mellitus, and hypothyroidism. Both patients with BD in remission and in mania exhibited increased plasma levels of Klotho in comparison with controls. There was no significant difference between patients in mania and patients in remission regarding the levels of Klotho. Conclusion Klotho-related pathway is altered in BD. Contrary to our original hypothesis, our sample of patients with BD presented increased plasma levels of Klotho in comparison with controls. Elevated levels of Klotho in long-term BD patients may be associated with the disorder progression. Further studies are needed to better understand the role of Klotho in BD and other mood disorders. |
| Databáze: | OpenAIRE |
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