TNF-α-308G/A polymorphisms and nasopharyngeal cancer risk: a meta-analysis
| Autor: | Li Xie, Yan Deng, Shan Li, Xiao-Nan Liang, Xue Qin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Tumor Necrosis Factor-alpha Carcinoma Subgroup analysis Nasopharyngeal Neoplasms General Medicine Odds ratio Publication bias Bioinformatics medicine.disease Polymorphism Single Nucleotide Confidence interval Otorhinolaryngology Nasopharyngeal carcinoma Gene Frequency Meta-analysis Internal medicine medicine Head and neck surgery Humans Genetic Predisposition to Disease business Nasopharyngeal cancer |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 270(5) |
| ISSN: | 1434-4726 |
| Popis: | Previous evidence has indicated that the polymorphism of tumor necrosis factor-alpha (TNF-α) is a risk factor for various cancers, however, the association between TNF-α-308G/A polymorphism and nasopharyngeal carcinoma (NPC) remains controversial and ambiguous. The aim of this study is to clarify the association between TNF-α polymorphism and NPC using meta-analysis. A meta-analysis based on five eligible case–control studies involving 499 cases and 1,470 controls was carried out to summarize the data on the association between TNF-α-308G/A polymorphism and NPC risk. Odds ratios (OR) with 95 % confidence intervals (95 % CI) were used to assess the strength of this association in the fixed-effect model. The pooled analyses showed no significant association between TNF-α-308G/A polymorphism and NPC (AA vs. GG: OR = 1.38, P = 0.193; GA vs. GG: OR = 0.92, P = 0.585; GA + AA vs. GG: OR = 1.00, P = 0.972; AA vs. GA + GG: OR = 1.44, P = 0.138). We also categorized by geographic location (non-Asian or Asian) for subgroup analysis; the results also showed no significant association between TNF-α-308G/A polymorphism and NPC risk in all of the comparisons. No publication bias was observed in this study (t = −0.11, P = 0.918, 95 % CI = −4.893–4.559). No significant association was found between TNF-α-308G/A polymorphism and the risk for NPC. |
| Databáze: | OpenAIRE |
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