Rose Hip and Lactobacillus plantarum DSM 9843 Reduce Ischemia/Reperfusion Injury in the Mouse Colon
| Autor: | Christina Stene, Göran Molin, Henrik Thorlacius, Bengt Jeppsson, Åsa Håkansson, Andrada Mihaescu, Siv Ahrné |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
lactobacilli Physiology Ischemia Gastroenterology and Hepatology Pharmacology In Vitro Techniques Rosa law.invention Caecum Lipid peroxidation chemistry.chemical_compound Mice Phenols law Oral administration Malondialdehyde medicine Animals Intestinal Mucosa Cecum polyphenols chemistry.chemical_classification Flavonoids rose hip Reactive oxygen species Mice Inbred BALB C biology business.industry Gastroenterology Polyphenols food and beverages medicine.disease biology.organism_classification reperfusion Disease Models Animal chemistry Reperfusion Injury Immunology Colorimetry Lipid Peroxidation ischaemia Phytotherapy business Reperfusion injury Lactobacillus plantarum |
| Zdroj: | Digestive Diseases and Sciences; 51(11), pp 2094-2101 (2006) |
| ISSN: | 1573-2568 |
| Popis: | Ischaemia/reperfusion (I/R) of the colon is an inflammatory condition that leads to tissue injury where reactive oxygen species play a central role. Rose hip is rich in biologically active polyphenols with antioxidative properties, which may be important in prevention of lipid peroxidation. L. plantarum DSM 9843 possesses enzymatic activity towards polyphenols. The objective of this study was to define the effect of oral administration of L. plantarum and rose hip in I/R injury. Administration of rose hip and L. plantarum significantly decreased MDA levels in caecum tissue and Enterobacteriaceae counts in caecum stool. A positive correlation between MDA levels and Enterobacteriaceae counts was found. The results support a synergistic/additive role of rose hip and L. plantarum in reducing lipid peroxidation. Therefore rose hip and L. plantarum may be used as a pretreatment to tissue injuries, e.g. colonic surgery, organ transplantation and vascular surgery. |
| Databáze: | OpenAIRE |
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