Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study

Autor: Shams El Arifeen, Yukiko Wagatsuma, Evana Akhtar, Iqbal Hossain, Nure Alam Afsar, Eva-Charlotte Ekström, Towfida Jahan Siddiqua, Tahmeed Ahmed, Ahsanul Haq, Anjan Kumar Roy, Rubhana Raqib
Jazyk: angličtina
Rok vydání: 2022
Předmět:
prenatal supplementation
RC620-627
Physiology
preadolescent children
Pediatrics
RJ1-570
Cohort Studies
Pregnancy
Vitamin D and neurology
Humans
Medicine
Micronutrients
Child
Nutritional diseases. Deficiency diseases
Bangladesh
Prenatal nutrition
Nutrition and Dietetics
business.industry
Public Health
Environmental and Occupational Health
Infant
Obstetrics and Gynecology
Pediatrik
Public Health
Global Health
Social Medicine and Epidemiology
Original Articles
Gynecology and obstetrics
Anthropometry
Micronutrient
medicine.disease
growth biomarkers
Näringslära
Malnutrition
Folkhälsovetenskap
global hälsa
socialmedicin och epidemiologi
MINIMat
Dietary Supplements
Pediatrics
Perinatology and Child Health
RG1-991
Gestation
Original Article
Birth Cohort
Female
Underweight
medicine.symptom
business
Birth cohort
Biomarkers
anthropometric indices
Zdroj: Maternal and Child Nutrition, Vol 18, Iss 1, Pp n/a-n/a (2022)
Maternal & Child Nutrition
ISSN: 1740-8695
1740-8709
Popis: Little is known about the usefulness of biomarkers to study the influence of prenatal nutrition supplementation in improving child growth. Anthropometry is not always straightforward to understand how nutrition might impact growth, especially in settings with high rates of malnutrition and infections. We examined the effects of prenatal supplementation on growth and growth biomarkers and the relationship between anthropometric measures and growth biomarkers of children at 4.5 and 9 years of age. Children were enrolled from a longitudinal cohort, where mothers were randomized into daily supplementation with either early‐food (≤9 gestation week [GW]) or usual‐food (~20 GW) (608 kcal 6 days/week); they were further randomized to receive 30‐mg or 60‐mg iron with 400‐μg folic acid, or multiple micronutrients (MM) in rural Bangladesh. Anthropometric data were collected from mothers at GW8 and children at 4.5 (n = 640) and 9 years (n = 536). Fasting blood was collected from children at each age. Early‐food supplementation showed reduced stunting and underweight at 4.5 and 9 years age respectively compared to usual‐food. Prenatal supplementations did not have any effect on growth biomarkers except for STAT5b expression which was lower in the early‐food compared to the usual‐food group (β = −0.21; 95 CI% = −0.36, −0.07). Plasma concentrations of 25‐hydroxy vitamin D and calcium were both inversely associated with weight‐for‐age and body mass index‐for‐age Z‐scores at 9 years, particularly in early‐food and MM groups. Although there was minimal effect on child growth by prenatal supplementations, the associations of biomarkers with anthropometric indices were predominantly driven by timing of food or MM supplementations.
Databáze: OpenAIRE
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