Immunosuppression as a risk factor forCOVID ‐19: a meta‐analysis
| Autor: | William Connell, Nik S. Ding, Daniel Tassone, Ryan C. Ungaro, Alexander Jv Thompson, Yijuan Ding, Ping An, Tanya Lee |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine COVID‐19 Risk Factors Internal medicine Pandemic Internal Medicine medicine Humans 030212 general & internal medicine Risk factor education Pandemics immunocompromised host risk Immunosuppression Therapy education.field_of_study immunosuppression business.industry COVID-19 Immunosuppression Original Articles infection Confidence interval Meta-analysis Cohort Original Article business |
| Zdroj: | Internal Medicine Journal |
| ISSN: | 1445-5994 1444-0903 |
| DOI: | 10.1111/imj.15142 |
| Popis: | Background While immunosuppression poses a theoretical increase in the risk of COVID‐19, the nature of this relationship is yet to be ascertained. Aims To determine whether immunosuppressed patients are at higher risk of COVID‐19 to help inform the management of patients receiving immunosuppressant therapies during the pandemic. Methods We performed a random‐effects meta‐analysis of data from studies that reported on the prevalence of immunosuppression among patient cohorts with COVID‐19. Results Sixty full‐text publications were identified. In total, six individual studies were included in the final analysis, contributing a total of 10 049 patients with COVID‐19 disease. The prevalence of immunosuppressed patients among the study cohorts with COVID‐19 ranged from 0.126% to 1.357%. In the pooled cohort a total of 64/10 049 (0.637%) patients with COVID‐19 disease was immunosuppressed. Observed to expected ratios were used to compare the prevalence of immunosuppression in cohorts with confirmed COVID‐19 disease to the background prevalence of immunosuppression in the general community. The observed to expected ratio of immunosuppression among patients with COVID‐19 illness, relative to the general community, was 0.12 (95% confidence interval: 0.05–0.27). Conclusions Compared to the general population, immunosuppressed patients were not at significantly increased risk of COVID‐19 infection. This finding provides support for current expert consensus statements, which have recommended the continuation of immunosuppressant therapy in the absence of COVID‐19. |
| Databáze: | OpenAIRE |
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