Immunomodulatory activity of various fractions derived from Physalis angulata L extract
| Autor: | Woei-Song Kan, Mei-Hui Won, Hsüch-Ching Chiang, Emily Hone, Shyh-Jen Shih, Yee-Shin Lin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Lipopolysaccharides
Cellular immunity Lipopolysaccharide Lymphocyte Drug Evaluation Preclinical Physalis angulata Pharmacology Lymphocyte Activation chemistry.chemical_compound Lactones Mice medicine Animals Secosteroids Phytohemagglutinins Mice Inbred BALB C Mice Inbred C3H Traditional medicine biology Biological activity Drug Synergism General Medicine biology.organism_classification Antineoplastic Agents Phytogenic medicine.anatomical_structure Complementary and alternative medicine chemistry Cell culture Physalis Physalin Steroids Drugs Chinese Herbal |
| Zdroj: | The American journal of Chinese medicine. 20(3-4) |
| ISSN: | 0192-415X |
| Popis: | The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice. |
| Databáze: | OpenAIRE |
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