Clinical significance of a microRNA signature for the identification and predicting prognosis in colorectal cancers with mucinous differentiation
| Autor: | Francesc Balaguer, Juan Ruiz-Bañobre, Miren Alustiza Fernández, Miguel Pera, Roshni Roy, Ajay Goel, Rodrigo Jover, Rafael López-López, Oscar Murcia |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Mucinous Differentiation Colorectal cancer Biomarker panel Disease 03 medical and health sciences 0302 clinical medicine Internal medicine microRNA Biomarkers Tumor Humans Medicine Mucinous carcinoma Clinical significance neoplasms Cancer Biomarkers and Molecular Epidemiology Aged Retrospective Studies business.industry Cell Differentiation General Medicine Prognosis medicine.disease Adenocarcinoma Mucinous digestive system diseases Gene Expression Regulation Neoplastic Survival Rate MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Female Identification (biology) Colorectal Neoplasms business Follow-Up Studies |
| Zdroj: | Carcinogenesis |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | Accumulating evidence supports the fact that the mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative of a particular CRC subtype with distinct clinical and molecular features. In addition, the prognostic significance of the mucinous carcinoma (MC) subtype remains poorly understood and biomarkers have been barely explored in this disease. Herein, we have performed a systematic and comprehensive analysis in MCs and non-MCs and identified a panel of microRNAs (miRNAs) that are differentially expressed between these two subtypes of CRC. Next, we interrogated their clinical significance and demonstrated their robust diagnostic and prognostic clinical ability in CRCs with mucinous differentiation. Finally, we established an integrative risk-assessment model by combining the miRNA-based risk scores together with TNM staging, which was a superior predictor of prognosis in mucinous CRC patients. Collectively, we report a novel miRNA biomarker panel for the identification and predicting survival in CRC patients with mucinous differentiation. |
| Databáze: | OpenAIRE |
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