Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy
| Autor: | Jérôme Devaux, Maya Belghazi, Yumako Miura, Anna Hiu Yi Wong, Yuki Fukami, Hiroo Ichikawa, Takayuki Inoue, Norito Kokubun, Constance Manso, Kenji Sekiguchi, Nobuhiro Yuki |
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| Přispěvatelé: | Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Microbiology and Medicine, National University of Singapore, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), National University of Singapore (NUS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Chronic inflammatory demyelinating polyneuropathy Serology 0302 clinical medicine Japan [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] 80 and over Child Chronic Inflammatory Demyelinating ComputingMilieux_MISCELLANEOUS Aged 80 and over biology Incidence Middle Aged 3. Good health [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology Biomarker (medicine) [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female medicine.symptom Antibody Adult Ataxia Adolescent Polyradiculoneuropathy Risk Assessment 03 medical and health sciences Young Adult Sensory ataxia Age Distribution medicine Humans Nerve Growth Factors Autoantibodies Aged Cerebellar ataxia business.industry Autoantibody medicine.disease 030104 developmental biology Polyradiculoneuropathy Chronic Inflammatory Demyelinating Immunoglobulin G Immunology biology.protein Neurology (clinical) business Cell Adhesion Molecules 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Neurology Neurology, American Academy of Neurology, 2016, 86 (9), pp.800--807. ⟨10.1212/WNL.0000000000002418⟩ Neurology, American Academy of Neurology, 2016, 86 (9), pp.800-807. ⟨10.1212/WNL.0000000000002418⟩ Neurology, 2016, 86 (9), pp.800--807. ⟨10.1212/WNL.0000000000002418⟩ |
| ISSN: | 0028-3878 1526-632X |
| DOI: | 10.1212/WNL.0000000000002418⟩ |
| Popis: | International audience; OBJECTIVE: We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.ăMETHODS: In sera from 533 patients with CIDP, anti-NF155 IgG4 antibodies were detected by ELISA. Binding of IgG antibodies to central and peripheral nerves was tested.ăRESULTS: Anti-NF155 IgG4 antibodies were identified in 38 patients (7%) with CIDP, but not in disease controls or normal participants. These patients were younger at onset as compared to 100 anti-NF155-negative patients with CIDP. Twenty-eight patients (74%) presented with sensory ataxia, 16 (42%) showed tremor, 5 (13%) presented with cerebellar ataxia associated with nystagmus, 3 (8%) had demyelinating lesions in the CNS, and 20 of 25 (80%) had poor response to IV immunoglobulin. The clinical features of the antibody-positive patients were statistically more frequent as compared to negative patients with CIDP (n = 100). Anti-NF155 IgG antibodies targeted similarly central and peripheral paranodes.ăCONCLUSION: Anti-NF155 IgG4 antibodies were associated with a subgroup of patients with CIDP showing a younger age at onset, ataxia, tremor, CNS demyelination, and a poor response to IV immunoglobulin. The autoantibodies may serve as a biomarker to improve patients' diagnosis and guide treatments. |
| Databáze: | OpenAIRE |
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