Assessment of oxidative/nitrosative stress biomarkers and DNA damage in Haemonchus contortus, following exposure to zinc oxide nanoparticles
| Autor: | Farhad Farhang-Pajuh, Bijan Esmaeilnejad, Awat Samiei, Yousef Mirzaei |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Livestock Antioxidant DNA damage medicine.medical_treatment Metal Nanoparticles Pharmacology Nitric Oxide medicine.disease_cause Antioxidants Nitric oxide Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound medicine Animals Anthelmintic Anthelmintics biology 030108 mycology & parasitology biology.organism_classification Oxidative Stress 030104 developmental biology chemistry Nitrosative Stress Catalase biology.protein Female Haemonchus Parasitology Lipid Peroxidation Zinc Oxide Haemonchiasis Biomarkers Oxidative stress DNA Damage Haemonchus contortus medicine.drug |
| Zdroj: | Acta Parasitologica. 63:563-571 |
| ISSN: | 1896-1851 1230-2821 |
| DOI: | 10.1515/ap-2018-0065 |
| Popis: | Drug resistance in helminth parasites has incurred several difficulties to livestock industry and ranked among the top public health concerns. Therefore, seeking for new agents to control parasites is an urgent strategy. In the recent years, metallic nanoparticles have been considerably evaluated for anthelmintic effects. The current research was conducted to assess possible anthelmintic impacts of zinc oxide nanoparticles (ZnO-NPs) on a prevalent gastrointestinal nematode, H. contortus. Moreover, several biomarkers of oxidative/nitrosative stress and DNA damage were measured. Various concentrations of the nanoparticle were prepared and incubated with the worms for 24 hours. The parasite mobility, mortality rate, antioxidant enzymes activities (SOD, Catalase and GSH-Px), lipid peroxidation, total antioxidant status as well as nitric oxide (NO) contents and DNA damage were determined. ZnO-NPs exerted significant wormicidal effects via induction of oxidative/nitrosative stress and DNA damage. Conclusively, ZnO-NPs can be utilized as a novel and potential agent to control and treatment of helminth parasitic infections. |
| Databáze: | OpenAIRE |
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