Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205
| Autor: | Kui Hong, Fan-Dong Kong, Dongbo Xu, Tian Erli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Circular dichroism anti-microbial 010405 organic chemistry Chemistry Stereochemistry genetic dereplication Bioactive molecules mangrove Streptomyces Pharmaceutical Science 01 natural sciences 0104 chemical sciences 03 medical and health sciences lcsh:Biology (General) antiproliferative Drug Discovery Gene cluster Mangrove Streptomyces qinglanensis Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 030304 developmental biology |
| Zdroj: | Marine Drugs, Vol 18, Iss 255, p 255 (2020) Marine Drugs Volume 18 Issue 5 |
| ISSN: | 1660-3397 |
| Popis: | Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A&ndash C (3&ndash 5) were identified from mangrove Streptomyces qinglanensis 172205 with &ldquo genetic dereplication,&rdquo which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2&ndash 4 showed weak antiproliferative activities. |
| Databáze: | OpenAIRE |
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