Similarities between the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and treatment
Autor: | Hani Alothaid, Mohammed S K Aldughaim, Sufana AlMashhadi, Karim El Bakkouri, Ahmed A. Al-Qahtani |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Drug COVID19 viruses media_common.quotation_subject Hepatitis C virus Pneumonia Viral Biophysics Hepacivirus Review Disease peg-IFN medicine.disease_cause Bioinformatics Biochemistry Betacoronavirus 03 medical and health sciences 0302 clinical medicine Pandemic medicine Animals Humans Pandemics Ion channel media_common SARS-CoV-2 business.industry fungi COVID-19 ion channels virus diseases Hepatitis C immune responses 030104 developmental biology Ion homeostasis HCV Ritonavir Coronavirus Infections business Viral load 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Channels article-version (VoR) Version of Record |
ISSN: | 1933-6969 1933-6950 |
Popis: | The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted an urgent need to identify effective medicines for the prevention and treatment of the disease. A comparative analysis between SARS-CoV-2 and Hepatitis C Virus (HCV) can expand the available knowledge regarding the virology and potential drug targets against these viruses. Interestingly, comparing HCV with SARS-CoV-2 reveals major similarities between them, ranging from the ion channels that are utilized, to the symptoms that are exhibited by patients. Via this comparative analysis, and from what is known about HCV, the most promising treatments for COVID-19 can focus on the reduction of viral load, treatment of pulmonary system damages, and reduction of inflammation. In particular, the drugs that show most potential in this regard include ritonavir, a combination of peg-IFN, and lumacaftor-ivacaftor. This review anaylses SARS-CoV-2 from the perspective of the role of ion homeostasis and channels in viral pathomechanism. We also highlight other novel treatment approaches that can be used for both treatment and prevention of COVID-19. The relevance of this review is to offer high-quality evidence that can be used as the basis for the identification of potential solutions to the COVID-19 pandemic. |
Databáze: | OpenAIRE |
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