In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes
| Autor: | Gabriele M. König, Clarissa Gerhäuser, Sabine Parys, Stefan Kehraus, Karl-Werner Glombitza, Karin Klimo, Anja Krick, Shmuel Carmeli |
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| Rok vydání: | 2010 |
| Předmět: |
Antioxidant
Oxygen radical absorbance capacity DPPH Radical medicine.medical_treatment Phloroglucinol Fucus vesiculosus Plant Science Horticulture Biochemistry Phlorotannin Antioxidants Inhibitory Concentration 50 Mice chemistry.chemical_compound Picrates Cell Line Tumor Neoplasms Terphenyl Compounds medicine Animals Cytochrome P-450 Enzyme Inhibitors Humans Phenols Molecular Biology chemistry.chemical_classification biology Aromatase Inhibitors Plant Extracts Phenyl Ethers Biphenyl Compounds General Medicine biology.organism_classification Antineoplastic Agents Phytogenic chemistry Fucus Nuclear chemistry |
| Zdroj: | Phytochemistry. 71:221-229 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2009.10.020 |
| Popis: | Within a project focusing on the chemopreventive potential of algal phenols, two phloroglucinol derivatives, belonging to the class of fucophlorethols, and the known fucotriphlorethol A were obtained from the ethanolic extract of the brown alga Fucus vesiculosus L. The compounds trifucodiphlorethol A and trifucotriphlorethol A are composed of six and seven units of phloroglucinol, respectively. The compounds were examined for their cancer chemopreventive potential, in comparison with the monomer phloroglucinol. Trifucodiphlorethol A, trifucotriphlorethol A as well as fucotriphlorethol A were identified as strong radical scavengers, with IC 50 values for scavenging of 1,1-diphenyl-2 picrylhydrazyl radicals (DPPH) in the range of 10.0–14.4 μg/ml. All three compounds potently scavenged peroxyl radicals in the oxygen radical absorbance capacity (ORAC) assay. In addition, the compounds were shown to inhibit cytochrome P450 1A activity with IC 50 values in the range of 17.9–33 μg/ml, and aromatase (Cyp19) activity with IC 50 values in the range of 1.2–5.6 μg/ml. |
| Databáze: | OpenAIRE |
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