Combined effect of prenatal solvent exposure and GSTT1 or GSTM1 polymorphisms in the risk of birth defects

Autor: Sylvaine Cordier, Isabelle Coiffec, Ronan Garlantézec, Catherine Celebi, Cécile Chevrier
Přispěvatelé: Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Rok vydání: 2012
Předmět:
Male
Embryology
MESH: Logistic Models
MESH: Solvents
MESH: Occupational Exposure
Cohort Studies
chemistry.chemical_compound
MESH: Pregnancy
0302 clinical medicine
Pregnancy
glutathione transferase
Genotype
030212 general & internal medicine
MESH: Maternal Exposure
Abortion
Therapeutic
Prospective cohort study
MESH: Cohort Studies
congenital abnormalities
0303 health sciences
MESH: Risk
MESH: Abortion
Therapeutic
Obstetrics
Confounding
MESH: Genetic Predisposition to Disease
MESH: Congenital Abnormalities
General Medicine
Stillbirth
Fetal Blood
MESH: Case-Control Studies
3. Good health
MESH: Stillbirth
[SDV.TOX]Life Sciences [q-bio]/Toxicology
MESH: Live Birth
Female
France
Live Birth
Adult
Risk
medicine.medical_specialty
Offspring
Biology
03 medical and health sciences
Fetus
maternal exposure
MESH: Polymorphism
Genetic
medicine
Humans
Genetic Predisposition to Disease
MESH: Fetal Blood
030304 developmental biology
MESH: Glutathione Transferase
Polymorphism
Genetic
MESH: Humans
MESH: Adult
MESH: Fetus
occupational exposure
Odds ratio
medicine.disease
MESH: Male
Confidence interval
Surgery
MESH: France
Logistic Models
solvents
chemistry
Case-Control Studies
Pediatrics
Perinatology and Child Health
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Solvent exposure
MESH: Female
Developmental Biology
Zdroj: Birth Defects Research Part A: Clinical and Molecular Teratology
Birth Defects Research Part A: Clinical and Molecular Teratology, Wiley, 2012, 94 (6), pp.481-5. ⟨10.1002/bdra.23018⟩
Birth Defects Research Part A: Clinical and Molecular Teratology, 2012, 94 (6), pp.481-5. ⟨10.1002/bdra.23018⟩
ISSN: 1542-0752
1542-0760
DOI: 10.1002/bdra.23018
Popis: International audience; Exposure to solvents during pregnancy has long been suspected to increase the risk of congenital malformations. Glutathione S-transferases (GSTs) are enzymes essential for the detoxification of various chemicals. Our objective here was to assess whether GST polymorphisms might modify the association between maternal solvent exposure and the risk of birth defects. A prospective cohort included 3421 pregnant women in Brittany, France (2002-2006). Occupational exposure to solvents was assessed from a job-exposure matrix. Congenital malformations were diagnosed among livebirths, stillbirths, and medical pregnancy terminations. Using a nested case-control design, 32 babies with major birth defects were compared to 348 normal births for babies' cord blood genotypes (at GSTT1 and GSTM1) and maternal occupational solvent exposure. Logistic models were used to adjust for potential confounders. The risk of major defects increased significantly in women with solvent exposure (20% of controls and 34% of cases). Frequencies of the null genotype of both the GSTT1 and GSTM1 genes were similar among controls and cases. There was a significantly increased risk of birth defects in GSTM1 not-null cord-blood genotype in pregnancies exposed to solvents (odds ratio [OR], 1.0 for not-null, not-exposed; OR, 4.0 for not-null, exposed; 95% confidence interval [CI], 1.4-11.2; OR, 1.6 for null, not-exposed; 95% CI, 0.6-3.9; OR, 1.0 for null, exposed; 95% CI, 0.2-4.7; p = 0.05). This nested case-control study suggests that the child's GSTM1 genotype modifies the risk of major birth defects among offspring of solvent-exposed women. Replication and additional investigations are necessary to confirm and elucidate these findings.
Databáze: OpenAIRE
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