Application of the ThinPrep Imaging System in Urine Cytology A Prospective Study
| Autor: | Bettien M. van Hemel, Albert J. H. Suurmeijer, Teus Ruitenbeek, Jolanda G. Haarsma, Henk Groen |
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| Přispěvatelé: | Methods in Medicines evaluation & Outcomes research (M2O), Reproductive Origins of Adult Health and Disease (ROAHD), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Diagnostic Imaging
Cancer Research medicine.medical_specialty Urinalysis IMAGER Cytodiagnosis CERVICAL CYTOLOGY ThinPrep Imager system specificity Urine CONVENTIONAL CYTOLOGY TIMES Predictive Value of Tests Cytology Conventional cytology medicine IMPLEMENTATION Humans Prospective Studies Prospective cohort study Urine cytology Gynecology SLIDES medicine.diagnostic_test accuracy business.industry Cancer medicine.disease sensitivity urine Oncology quality Predictive value of tests cytology Nuclear medicine business |
| Zdroj: | Cancer cytopathology, 121(8), 410-414. Wiley |
| ISSN: | 1934-662X |
| Popis: | BACKGROUND In this prospective study, for the first time, the authors compared the accuracy of reading urine specimens using the ThinPrep Imager System (TIS) with the accuracy of conventional screening for the detection of abnormal urine cells.METHODS ThinPrep slides were made from 1455 urine specimens and were read with conventional screening and with TIS. Findings were categorized as unsatisfactory or failure to read the slide, benign, or abnormal. The Cohen coefficient was calculated to determine inter-rater agreement between both methods. Urine samples that were followed by biopsies were used to compare the sensitivity, specificity, positive predictive value, and negative predictive value of both methods. From 22 urine specimens, the screening times were measured and compared.RESULTS There was substantial agreement between both methods ( score, 0.77). Of 175 urine specimens that were followed by bladder biopsies, for conventional screening, the sensitivity was 51.3%, specificity was 68.4%, the positive predictive value was 77.2%, and the negative predictive value was 40.2%; for TIS screening, the respective values were 54.6%, 68.4%, 78.3%, and 41.9%. The average time was 5.2 minutes for conventional screening and 3.9 minutes for TIS.CONCLUSIONS With a score of 0.77, the current study demonstrated a good correlation between reading urine specimens with conventional screening and with TIS. Using TIS resulted in slightly increased sensitivity, positive predictive value, and negative predictive value compared with conventional screening and had the same specificity. These results indicate that reading urine specimens using TIS is equally reliable as conventional cytology. Cancer (Cancer Cytopathol) 2013;121:410-4. (c) 2013 American Cancer Society.Application of the ThinPrep Imaging System for urine cytology is as reliable as conventional screening for the detection of abnormal urine cells. There is good correlation between both methods with almost equal sensitivity and specificity. |
| Databáze: | OpenAIRE |
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