Measures of anxiety, depression and stress in the antenatal and perinatal period following a stillbirth or neonatal death: a multicentre cohort study
| Autor: | Suzanne Thomas, Louise Stephens, Tracey A. Mills, Christine Hughes, Alan Kerby, Debbie M. Smith, Alexander E. P. Heazell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Hydrocortisone Perinatal Death Gestational Age Anxiety Cohort Studies Perceived Stress Pregnancy Surveys and Questionnaires Humans Pregnancy after loss Psychiatric Status Rating Scales Depression Research Neonatal Death Obstetrics and Gynecology Gynecology and obstetrics Stillbirth Middle Aged wm_20 ws_420 England Hair Analysis wq_20 RG1-991 Quality of Life Female Pregnancy Trimesters Pregnant Women Subsequent Pregnancy Stress Psychological wq_175 |
| Zdroj: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-9 (2021) Thomas, S, Stephens, L, Mills, T A, Hughes, C, Kerby, A, Smith, D & Heazell, A E P 2021, ' Measures of anxiety, depression and stress in the antenatal and perinatal period following a stillbirth or neonatal death : a multicentre cohort study ', BMC Pregnancy and Childbirth, vol. 21, no. 1, 818 . https://doi.org/10.1186/s12884-021-04289-0 |
| ISSN: | 1471-2393 |
| DOI: | 10.1186/s12884-021-04289-0 |
| Popis: | Background The grief associated with the death of a baby is enduring, however most women embark on another pregnancy, many in less than a year following their loss. Symptoms of anxiety and depression are reported to be increased in pregnancies after perinatal death, although effect on maternal stress is less clear. Variation between individual studies may result from differences in gestation at sampling, the questionnaire used and the type of antecedent perinatal death. We aimed to describe quantitative measures of anxiety, depression, stress and quality of life at different timepoints in pregnancies after perinatal death and in the early postnatal period. Methods Women recruited from three sites in the North-West of England. Women were asked to participate if a previous pregnancy had ended in a perinatal death. Participants completed validated measures of psychological state (Cambridge Worry Score, Edinburgh Postnatal Depression Score (EPDS), Generalized Anxiety Disorder 7-item score) and health status (EQ-5D-5L™ and EQ5D-Visual Analogue Scale) at three time points, approximately 15 weeks’ and 32 weeks’ gestation and 6 weeks postnatally. A sample of hair was taken at approximately 36 weeks’ gestation for measurement of hair cortisol in a subgroup of women. The hair sample was divided into samples from each trimester and cortisol measured by ELISA. Results In total 112 women participated in the study. Measures of anxiety and depressive symptoms decreased from the highest levels at 15 weeks’ gestation to 6-weeks postnatal (for example mean GAD-7: 15 weeks 8.2 ± 5.5, 6 weeks postnatal 4.4 ± 5.0, p Conclusions This study demonstrated heightened anxiety and depressive symptoms and elevated cortisol levels in women in pregnancies after a stillbirth or neonatal death which decrease as pregnancy progresses. Further studies are needed to determine optimal care for women to address these negative psychological consequences. |
| Databáze: | OpenAIRE |
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