Indications and efficacy of botulinum toxin in disorders of the gastrointestinal tract
| Autor: | Aditya Mandal, R J Robinson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal Diseases Achalasia Gastroenterology Gastrointestinal Agents Predictive Value of Tests Internal medicine medicine Humans Botulinum Toxins Type A Esophagus Gastrointestinal tract Anal fissure Gastrointestinal agent Hepatology business.industry medicine.disease Botulinum toxin Esophageal Achalasia Treatment Outcome medicine.anatomical_structure Anismus Sphincter of Oddi dysfunction Fissure in Ano business Follow-Up Studies medicine.drug |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 13:603-609 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/00042737-200105000-00024 |
| Popis: | In recent years, botulinum toxin type A (BT) has been found to be effective in the treatment of various spastic disorders of smooth muscle in the upper and lower gastrointestinal tract. The short-term efficacy of intrasphincteric injection of BT in achalasia is now well established, however, because of the chronic nature of the disease, patients will require repeated injections at regular intervals. In contrast, after a single injection into the anal sphincter, BT has impressively high healing rate with minimal side effects. BT remains a novel therapeutic approach in a range of other gastrointestinal motility disorders including diffuse oesophageal spasm, sphincter of Oddi dysfunction and anismus, and the list of its indications is increasing. BT seems to be safe but as its long-term effects remain unestablished, it should be used with caution in younger patients. In this review we discuss the mechanism of action, indications, efficacy and side-effects of BT with its use in various areas of gastrointestinal tract. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|