Environmental cues to guide stem cell fate decision for tissue engineering applications
| Autor: | Melissa J. Mahoney, Eben Alsberg, Horst A. von Recum |
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| Rok vydání: | 2006 |
| Předmět: |
Clinical Biochemistry
Clinical uses of mesenchymal stem cells Cell Communication Biology Regenerative Medicine Regenerative medicine Tissue engineering Drug Discovery Animals Humans Cell Lineage Progenitor cell Growth Substances Cell Proliferation Neurons Pharmacology Tissue Engineering Regeneration (biology) Mesenchymal stem cell Endothelial Cells Cell Differentiation Mesenchymal Stem Cells Genetic Therapy Neural stem cell Immunology Cytokines Stem cell Neuroscience |
| Zdroj: | Expert Opinion on Biological Therapy. 6:847-866 |
| ISSN: | 1744-7682 1471-2598 |
| Popis: | The human body contains a variety of stem cells capable of both repeated self-renewal and production of specialised, differentiated progeny. Critical to the implementation of these cells in tissue engineering strategies is a thorough understanding of which external signals in the stem cell microenvironment provide cues to control their fate decision in terms of proliferation or differentiation into a desired, specific phenotype. These signals must then be incorporated into tissue regeneration approaches for regulated exposure to stem cells. The precise spatial and temporal presentation of factors directing stem cell behaviour is extremely important during embryogenesis, development and natural healing events, and it is possible that this level of control will be vital to the success of many regenerative therapies. This review covers existing tissue engineering approaches to guide the differentiation of three disparate stem cell populations: mesenchymal, neural and endothelial. These progenitor cells will be of central importance in many future connective, neural and vascular tissue regeneration technologies. |
| Databáze: | OpenAIRE |
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