Development of a safe and scalable route towards a tau PET tracer precursor
| Autor: | Philipp Cueni, Matthias Koerner, Dieter Muri, Bjoern Bartels |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Clinical Biochemistry
Carbazoles Pharmaceutical Science tau Proteins 010402 general chemistry 01 natural sciences Biochemistry Catalysis chemistry.chemical_compound Alzheimer Disease TRACER Drug Discovery Humans Organic chemistry Pet tracer Molecular Biology Amination 010405 organic chemistry Organic Chemistry Buchwald–Hartwig amination Key features Combinatorial chemistry 0104 chemical sciences Stille reaction chemistry Positron-Emission Tomography Molecular Medicine Palladium Derivative (chemistry) |
| Zdroj: | Bioorganic & Medicinal Chemistry. 26:970-976 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2017.10.007 |
| Popis: | A scalable 5-step synthesis of the diazacarbazole derivative 1 used as tau PET tracer precursor is reported. Key features of this synthesis include a Buchwald-Hartwig amination, a Pd catalyzed CH activation and a Suzuki-Miyaura cross-coupling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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