COMPARATIVE ASSESSMENT OF EFFECT OF COMBINED DRUGS OF ACE INHIBITOR AND DIURETIC ('NOLIPREL FORTE' AND 'CAPOZIDE') ON CARDIOVASCULAR REMODELING IN HYPERTENSIVE PATIENTS
| Autor: | A. V. Legkiy, T. D. Kaplanov, Yu. M. Lopatin, L. P. Anisimova, V. V. Ivanenko, N. V. Ryasancevа |
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| Rok vydání: | 2005 |
| Předmět: |
arterial hypertension
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Ambulatory blood pressure суточное мониторирование артериального давления medicine.medical_treatment комбинация ингибитора АПФ и диуретика ремоделирование миокарда и сосудистой стенки RM1-950 pulse wave speed артериальная гипертония Hydrochlorothiazide Internal medicine medicine Perindopril Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) business.industry lcsh:RM1-950 Indapamide Captopril cardio-vascular remodeling combination of ace inhibitor and diuretic скорость пульсовой волны lcsh:Therapeutics. Pharmacology Endocrinology medicine.anatomical_structure lcsh:RC666-701 RC666-701 ACE inhibitor Cardiology Therapeutics. Pharmacology Diuretic Cardiology and Cardiovascular Medicine business ambulatory blood pres-sure monitoring medicine.drug Artery |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 1, Iss 3, Pp 17-23 (2015) |
| ISSN: | 2225-3653 1819-6446 |
| DOI: | 10.20996/1819-6446-2005-1-3-17-23 |
| Popis: | Aim. To assess antihypertensive efficacy and effect on cardio-vascular remodeling of combined drugs of ACE inhibitor and diuretic, “Noliprel forte” (NF) and “Capozide” (CA), in hypertensive high risk patients.Material and methods. 50 hypertensive (II grade) patients (25 men and 25 women, 19-65 years old) with high cardio-vascular risk took part in comparative opened randomized study. No one of patients received antihypertensive therapy before study. All patients were randomized for therapy with one of combined drug of ACE inhibitors and diuretic. 25 patients took NF (perindopril 4 mg and indapamide 1,25 mg), and 25 patients -CA (captopril 50 mg and hydrochlorothiazide 25 mg). Duration of observation period was 6 months. Before study, after 3 and 6 months of therapy ambulatory blood pressure monitoring (ABPM), echocardiography, cardiac and vessel Dopplerography, ultrasound scanning of general carotid arteries with detection of intima-media thickness (IMT), pulse wave speed (PWS) were held in all patients. Blood bio-chemical analysis was done also.Results. After 3 months 2 patients in NF group and 4 ones in CA group were required to reinforce of ther-apy with additional administration of perindoprile 4 mg and captopril 50 mg respectively. As a result of 6-month of therapy in NF group systolic dlood pressure (BP) decreased in 14,0% (рConclusion. 6-month therapy with NF showed high antihypertensive efficacy for both of drugs, which did not accompany with cerebral blood flow disturbances. Both drugs also showed an ability for positive effect on cardio-vascular remodeling (with NF priority), improvement of artery wall elasticity. NF, unlike CA, did not increase in plasma uric acid level. |
| Databáze: | OpenAIRE |
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