Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients
| Autor: | Antonio González-Chávez, Galileo Escobedo, Nayeli Garibay-Nieto, Ruy Pérez-Tamayo, Gabriela Paredes-Turrubiarte, Vito S. Hernández, Beatriz Y. Salazar-Vázquez, José Manuel Fragoso |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Serum 0301 basic medicine medicine.medical_specialty Adolescent medicine.medical_treatment Systemic inflammation Severity of Illness Index General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences chemistry.chemical_compound Insulin resistance Liver Function Tests Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Aged Ultrasonography Tumor Necrosis Factor-alpha business.industry Insulin Fatty liver General Medicine Middle Aged medicine.disease Interleukin-10 Obesity Morbid 030104 developmental biology Endocrinology Liver chemistry Homeostatic model assessment Female Glycated hemoglobin Liver function Steatosis medicine.symptom business |
| Zdroj: | Clinical and Experimental Medicine. 16:193-202 |
| ISSN: | 1591-9528 |
| DOI: | 10.1007/s10238-015-0347-4 |
| Popis: | Morbid obesity has been shown to increase the risk to develop hepatic steatosis, also referred to as non-alcoholic fatty liver disease (NAFLD). Emerging evidence suggests that the severity of NAFLD may associate with increased serum levels of inflammatory markers as well as decreased concentration of mediators with anti-inflammatory actions, such as tumor necrosis factor alpha (TNF-α) and interleukin (IL) 10, respectively. We thus examined the serum levels of TNF-α and IL-10 in 102 morbidly obese women and men (body mass index 40 kg/m(2)), exhibiting different grades of NAFLD. Blood glucose, glycated hemoglobin, insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, high- and low-density lipoproteins, parameters of liver function, TNF-α, and IL-10 were measured in each subject. The stage of NAFLD was estimated by abdominal ultrasound imaging. In comparison with morbidly obese subjects without steatosis, morbidly obese patients with NAFLD showed increased age (39.23 ± 9.80 years), HOMA-IR (6.74 ± 1.62), total cholesterol (219.7 ± 9.58 mg/dl), aspartate aminotransferase (36.25 ± 3.24 UI/l), gamma-glutamyl transpeptidase (37.12 ± 3.41 UI/l), and TNF-α (37.41 ± 1.72 pg/ml) as well as decreased serum levels of IL-10 (61.05 ± 2.43 pg/ml). Interestingly, the systemic levels of TNF-α increased, while IL-10 decreased in accordance with the severity of NAFLD, which supports a role for systemic inflammatory mediators in promoting steatosis progression. Further clinical prospective studies need to be addressed to elucidate the role of TNF-α and IL-10 in the development of NAFLD while also establishing their clinical utility in the assessment of morbidly obese patients at higher risk to develop severe steatosis. |
| Databáze: | OpenAIRE |
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