Increased Tolerance of Leukemic Mice to Arabinosyl Cytosine with Schedule Adjusted to Circadian System
| Autor: | Dar Shong Hwang, Erhard Haus, Robert B. Sothern, John E. Pauly, Franz Halberg, Lawrence E. Scheving, Jüurgen F. W. Kühl, Sergio Cardoso, Ronald N. Shiotsuka |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Chemotherapy Time Factors Multidisciplinary medicine.medical_treatment Cytarabine Mice Inbred Strains Arabinosyl cytosine Drug Tolerance Pharmacology Biology Leukemia L1210 Circadian Rhythm Mice Inbred strain Drug tolerance Toxicity medicine Animals Circadian rhythm Increased tolerance Injections Intraperitoneal |
| Zdroj: | Science. 177:80-82 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.177.4043.80 |
| Popis: | Mice (BDF(1)) inoculated with L1210 leukemia survive for a statistically significantly longer span when four courses of arabinosyl cytosine are administered at 4-day intervals-not in courses consisting of eight equal doses at 3-hour intervals, but in sinusoidally increasing and decreasing 24-hour courses, the largest amount being given at previously mapped circadian and circannual times of peak host resistance to the drug. This finding relates to the many therapeutic situations involving rhythmic, and thus predictable, cycles in the host's tolerance of undesired effects from the agent used. |
| Databáze: | OpenAIRE |
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