Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors

Autor: Guo-Lin Liao, Shi-Quan Liu, Mengbin Qin, Jie-An Huang, Zhihai Liang, Hua-Qiang Ruan, Jianfu Qin, Guo-Du Tang, Peng Peng
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Multivariate analysis
Article Subject
Duodenum
030231 tropical medicine
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Feces
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Animals
Bile
Humans
Medicine
Aged
Retrospective Studies
Aged
80 and over
Cholangiopancreatography
Endoscopic Retrograde
Univariate analysis
Clonorchis sinensis
Endoscopic retrograde cholangiopancreatography
General Immunology and Microbiology
biology
medicine.diagnostic_test
business.industry
Pancreatic Diseases
Retrospective cohort study
General Medicine
Middle Aged
030108 mycology & parasitology
biology.organism_classification
medicine.disease
Confidence interval
Major duodenal papilla
Clonorchiasis
Female
business
Research Article
Zdroj: BioMed Research International, Vol 2020 (2020)
BioMed Research International
ISSN: 2314-6141
2314-6133
Popis: Background. Many epidemiological studies have investigated the risk factors for clonorchiasis, but endoscopic findings of this disease in endoscopic retrograde cholangiopancreatography (ERCP) have not been well characterized. In this study, we evaluated clonorchiasis in ERCP in patients with biliary and pancreatic diseases. Methods. This was a retrospective two-center study in hospitalized patients who received ERCP between January 2012 and October 2018. All patients were divided into clonorchiasis and nonclonorchiasis groups. Data were analyzed using univariate analysis and multivariate analyses. Results. A total of 1119 patients were included, and clonorchiasis was diagnosed in 19.2% patients. Detection of Clonorchis sinensis eggs in bile samples was higher than that in fecal samples (85.9% vs. 58.7%; P=0.001). In multivariate analysis, male patients (95% confidence interval (CI): 1.945–4.249, P=0.0001), age≤60 years old (95% CI: 1.212–2.474, P=0.003), patients with papilla fistula (95% CI: 0.081–0.900, P=0.033), and patients with a common bile duct (CBD) diameter<12 mm (95% CI: 1.093–2.130, P=0.013) were associated with clonorchiasis incidence. Nonclonorchiasis endoscopic diagnosis did not significantly correlate with clonorchiasis incidence (P>0.05). Conclusions. The detection of C. sinensis eggs was significantly higher in bile than in fecal samples; thus, bile samples represent a preferable sample for the diagnosis of clonorchiasis in patients with biliary obstruction. We found that male, age≤60 years old, and CBD diameter<12 mm were independent risk factors for clonorchiasis, while papilla fistula was a protective factor.
Databáze: OpenAIRE
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