Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles
| Autor: | Robert H. Grubbs, Steven W. Hetts, Carl M. Blumenfeld, Terilynn Moore, Michael D. Schulz, Mark W. Wilson, Mariam Aboian |
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| Rok vydání: | 2018 |
| Předmět: |
Swine
medicine.medical_treatment General Physics and Astronomy 02 engineering and technology Cardiovascular 01 natural sciences Polyethylene Glycols Drug Delivery Systems Neoplasms polycyclic compounds Nanotechnology Tissue Distribution lcsh:Science Magnetite Nanoparticles media_common Cancer Multidisciplinary Chemistry 021001 nanoscience & nanotechnology Heart Disease 5.1 Pharmaceuticals 6.1 Pharmaceuticals Development of treatments and therapeutic interventions 0210 nano-technology medicine.drug Biotechnology Drug media_common.quotation_subject Science Bioengineering Antineoplastic Agents 010402 general chemistry Systemic circulation General Biochemistry Genetics and Molecular Biology Article Magnetics In vivo medicine Animals Humans Doxorubicin Cisplatin Chemotherapy Myocardium Evaluation of treatments and therapeutic interventions General Chemistry DNA 0104 chemical sciences Rats genomic DNA Cancer research Magnetic nanoparticles lcsh:Q |
| Zdroj: | Nature communications, vol 9, iss 1 Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018) |
| Popis: | Chemotherapy agents are notorious for producing severe side-effects. One approach to mitigating this off-target damage is to deliver the chemotherapy directly to a tumor via transarterial infusion, or similar procedures, and then sequestering any chemotherapeutic in the veins draining the target organ before it enters the systemic circulation. Materials capable of such drug capture are yet to be fully realized. Here, we report the covalent attachment of genomic DNA to iron-oxide nanoparticles. With these magnetic materials, we captured three common chemotherapy agents—doxorubicin, cisplatin, and epirubicin—from biological solutions. We achieved 98% capture of doxorubicin from human serum in 10 min. We further demonstrate that DNA-coated particles can rescue cultured cardiac myoblasts from lethal levels of doxorubicin. Finally, the in vivo efficacy of these materials was demonstrated in a porcine model. The efficacy of these materials demonstrates the viability of genomic DNA-coated materials as substrates for drug capture applications. Chemotherapy agents are prone to producing severe side-effects, and their sequestration prior to their entering of the circulatory system is thus highly desirable. Here, the authors functionalize iron oxide nanoparticles with genomic DNA and achieve sequestration of doxorubicin, cisplatin, and epirubicin from biological solutions. |
| Databáze: | OpenAIRE |
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