Association between dietary folate intake and serum insulin-like growth factor-1 levels in healthy old women
| Autor: | Linda Berton, I. De Ronch, S. Carraro, M. De Rui, Alessandra Coin, G. Sergi, Elena Debora Toffanello, Francesco Bolzetta, Nicola Veronese, Enzo Manzato, S. Pizzato, F. Miotto |
|---|---|
| Přispěvatelé: | Carraro, S., Veronese, N., Bolzetta, F., De Rui, M., Berton, L., Pizzato, S., Toffanello, E.D., De Ronch, I., Miotto, F., Coin, A., Manzato, E., Sergi, G. |
| Rok vydání: | 2013 |
| Předmět: |
Calorie
Mediterranean diet Endocrinology Diabetes and Metabolism medicine.medical_treatment Physiology Riboflavin Diet Mediterranean Body Mass Index Eating Folic Acid Endocrinology Vitamin D and neurology Humans Medicine Food science Insulin-Like Growth Factor I Aged Aged 80 and over Immunoassay business.industry Vitamin E Confounding Micronutrient Cross-Sectional Studies Body Composition Female Folates IGF-1 Old people Mediterranean diet Energy Intake business Body mass index Biomarkers |
| Zdroj: | Growth Hormone & IGF Research. 23:267-271 |
| ISSN: | 1096-6374 |
| Popis: | Objective High serum levels of insulin-like growth factor-1 (IGF-1) seem to coincide with higher rates of some types of cancer and the risk of all-cause mortality in old people. Eating vegetables seems to reduce IGF-1 levels because they are rich in micronutrients such as vitamins. This study investigates the possible association between vitamin intake and IGF-1 levels in a representative group of healthy elderly women with Mediterranean dietary habits. Design This cross-sectional study included 124 healthy women with a mean age of 71.3 ± 4.2 years and a mean body mass index (BMI) of 27.37 ± 3.48 kg/m 2 attending a mild fitness program twice a week at public gyms in Padova. The main parameters considered were IGF-1 (measured by chemiluminescence) and diet, assessed on the basis of a 3-day record and a questionnaire on the frequency with which they usually ate certain foods. Results The mean IGF-1 level for the sample as a whole was 136.2 ± 38.9 μg/l, and was significantly lower in women with a higher folate intake (p = 0.04). On simple linear analysis, the vitamins found associated with serum IGF-1 levels were: folates (r: − 0.25; p = 0.003); vitamin E (r: − 0.21; p = 0.01); vitamin D (r: − 0.17; p = 0.03); and riboflavin (r: − 0.16; p = 0.03). After removing the effect of calorie, protein, carbohydrate and fat intake, and other known potential confounders (age, BMI, alcohol intake), only folate intake correlated with IGF-1 levels (r = − 0.17; p = 0.04). Conclusion A folate-rich diet could have the effect of lowering circulating IGF-1 levels in elderly women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect