Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai
Autor: | Eun La Kim, Jian Lin Li, Hung The Dang, Jongki Hong, Chong-Ok Lee, Dong-Kyoo Kim, Won Duk Yoon, Euikyung Kim, Yonghong Liu, Jee H. Jung |
---|---|
Rok vydání: | 2012 |
Předmět: |
Jellyfish
Scyphozoa Stereochemistry Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Biochemistry HeLa Inhibitory Concentration 50 chemistry.chemical_compound Ascomycota Cell Line Tumor biology.animal Drug Discovery Animals Humans Cytochalasin Cytotoxicity Molecular Biology Cytochalasin B Early Detection of Cancer Cell Death Dose-Response Relationship Drug Molecular Structure biology Organic Chemistry Absolute configuration biology.organism_classification Cytochalasins chemistry Cell culture Phoma Molecular Medicine |
Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:3126-3129 |
ISSN: | 0960-894X |
Popis: | Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved. |
Databáze: | OpenAIRE |
Externí odkaz: |