Neuronal tuning: Selective targeting of neuronal populations via manipulation of pulse width and directionality
| Autor: | Yuichiro Shirota, Walter Paulus, I. Halawa, Andreas Neef, Martin Sommer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male cTMS Materials science genetic structures Rest Pulse width Biophysics Stimulation 050105 experimental psychology lcsh:RC321-571 Young Adult 03 medical and health sciences 0302 clinical medicine rTMS Neuronal tuning Humans Directionality 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neurons Electromyography Pulse (signal processing) General Neuroscience 05 social sciences Motor Cortex Dendrites Evoked Potentials Motor Transcranial Magnetic Stimulation Inhibition Psychological nervous system Female Neurology (clinical) Pulse directionality 030217 neurology & neurosurgery Excitation Pulse-width modulation |
| Zdroj: | Brain Stimulation, Vol 12, Iss 5, Pp 1244-1252 (2019) |
| ISSN: | 1935-861X |
| DOI: | 10.1016/j.brs.2019.04.012 |
| Popis: | Introduction Motor evoked potentials (MEP) in response to anteroposterior transcranial (AP) magnetic stimulation (TMS) are sensitive to the TMS pulse shape. We are now able to isolate distinct pulse properties, such as pulse width and directionality and evaluate them individually. Different pulse shapes induce different effects, likely by stimulating different populations of neurons. This implies that not all neurons respond in the same manner to stimulation, possibly, because individual segments of neurons differ in their membrane properties. Objectives To investigate the effect of different pulse widths and directionalities of TMS on MEP latencies, motor thresholds and plastic aftereffects of rTMS. Methods Using a controllable pulse stimulator TMS (cTMS), we stimulated fifteen subjects with quasi-unidirectional TMS pulses of different pulse durations (40 μs, 80 μs and 120 μs) and determined thresholds and MEP AP latencies. We then compared the effects of 80 μs quasi-unidirectional pulses to those of 80 μs pulses with different pulse directionality characteristics (0.6 and 1.0 M ratios). We applied 900 pulses of the selected pulse shapes at 1 Hz. Results The aftereffects of 1 Hz rTMS depended on pulse shape and duration. 40 and 80 μs wide unidirectional pulses induced inhibition, 120 μs wide pulses caused excitation. Bidirectional pulses induced inhibition during the stimulation but had facilitatory aftereffects. Narrower pulse shapes caused longer latencies and higher resting motor thresholds (RMT) as compared to wider pulse shapes. Conclusions We can tune the aftereffects of rTMS by manipulating pulse width and directionality; this may be due to the different membrane properties of the various neuronal segments such as dendrites. Significance To date, rTMS frequency has been the main determinant of the plastic aftereffects. However, we showed that pulse width also plays a major role, probably by recruiting novel neuronal targets. |
| Databáze: | OpenAIRE |
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