Acid‐Cleavable Poly(ethylene glycol) Hydrogels Displaying Protein Release at pH 5

Autor:	Holger Frey, Jan Blankenburg, Hannah Pohlit, Johannes Ewald, Laura Besch, Wolfgang Tremel, Ronald E. Unger, Matthias Worm
Rok vydání:	2020
Předmět:	540 Chemistry and allied sciences Vinyl Compounds Biocompatible Materials Degree of polymerization 010402 general chemistry 01 natural sciences Catalysis Polyethylene Glycols Polymerization chemistry.chemical_compound Hydrolysis Polymer chemistry PEG ratio Copolymer medicine hydrogels Polymer Technologies chemistry.chemical_classification Full Paper Ethylene oxide 010405 organic chemistry Organic Chemistry Biochemistry and Molecular Biology Proteins protein release Hydrogels General Chemistry Polymer Full Papers Hydrogen-Ion Concentration Vinyl ether Polymerteknologi PEG 0104 chemical sciences copolymerization chemistry 540 Chemie drug delivery Self-healing hydrogels Methacrylates Biokemi och molekylärbiologi medicine.drug
Zdroj:	Chemistry (Weinheim an Der Bergstrasse, Germany)
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.201905310
Popis:	PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring‐opening copolymerization of ethylene oxide with 3,4‐epoxy‐1‐butene (EPB) and subsequent modification to introduce acid‐degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross‐linking. Copolymers with different molar ratios of EPB, molecular weights (M n) up to 10 000 g mol−1 and narrow dispersities (Đ Responsive gels: P(EG‐co‐isoEPB)MA, a PEG copolymer with acidic degradability under physiologically relevant pH is employed for hydrogels. The attached methacrylate units enable radical cross‐linking to form protein‐loaded hydrogels. Both the P(EG‐co‐isoEPB)MA copolymer as well as the respective hydrogels show rapid and tailorable hydrolysis at physiologically relevant pH (pH 5–6), despite excellent storage stability at neutral pH (pH 7.4).
Databáze:	OpenAIRE
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