Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H NMR
| Autor: | Véronique Gilard, Myriam Malet-Martino, R. Martino, D Desoubdzanne, Julie Vaysse, Stéphane Balayssac |
|---|---|
| Přispěvatelé: | Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Magnetic Resonance Spectroscopy
Health Toxicology and Mutagenesis Analytical chemistry Food Contamination Phenolphthalein Toxicology Body weight 01 natural sciences chemistry.chemical_compound 0404 agricultural biotechnology Limit of Detection Tandem Mass Spectrometry Weight loss Pharmaceutic Aids medicine Chromatography Complex matrix Synephrine 010401 analytical chemistry Public Health Environmental and Occupational Health Life Sciences 04 agricultural and veterinary sciences General Chemistry General Medicine Nuclear magnetic resonance spectroscopy 040401 food science 0104 chemical sciences 3. Good health chemistry Dietary Supplements Proton NMR Drug and Narcotic Control Anti-Obesity Agents medicine.symptom Drug Contamination Cyclobutanes Drugs Chinese Herbal Food Science medicine.drug Sibutramine |
| Zdroj: | Food Additives and Contaminants Food Additives and Contaminants, 2010, 27 (07), pp.903-916. ⟨10.1080/19440041003705821⟩ |
| DOI: | 10.1080/19440041003705821⟩ |
| Popis: | Twenty herbal medicines or dietary supplements marketed as natural slimming products were analysed by diffusion ordered spectroscopy (DOSY) 1H-nuclear magnetic resonance (NMR) and DOSY-COSY 1H-NMR. The method allows analysis of the whole sample with the detection of both active and inactive ingredients in these complex matrices. Among the 20 formulations analysed, two were strictly herbal and four had a composition corresponding to declared ingredients on the packaging or the leaflet. The others were all adulterated. Eight formulations contain sibutramine alone at doses ranging from 4.4 to 30.5 mg/capsule. Five formulations contain sibutramine (from 5.0 to 19.6 mg/capsule or tablet) in combination with phenolphthalein (from 4.4 to 66.1 mg/capsule), and the last formulation was adulterated with synephrine (19.5 mg/capsule). Quantification of the actives was carried out with 1H-NMR. Several other compounds were also characterized including methylsynephrine, vitaberin, sugars, vitamins, etc. DOSY NMR is thus proposed as a useful tool for detection of unexpected adulteration. |
| Databáze: | OpenAIRE |
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