Identification of the first case of SFTSV infection in the Hunan Province of China and epidemiological surveillance in the locality

Autor: Si-Xuan Long, Jie Wang, Wei-Min Cao, Liang Cai, Jia-hui Liu, Fang-Ling He, Liang-Yi Xie, Jin-Ru Wu, Qi-Zhi Luo, Hong Zhang, Zhong-Hui Pan, Zhifei Zhan, Fan Zhang, Lidong Gao, Yizhou Zou, Shi-Xiong Hu, Zhihong Deng, Qianlai Sun
Rok vydání: 2019
Předmět:
Male
Phlebovirus
0301 basic medicine
Antibodies
Viral
Serology
0302 clinical medicine
Seroepidemiologic Studies
Epidemiology
Prevalence
Child
education.field_of_study
Farmers
biology
Middle Aged
Infectious Diseases
Animals
Domestic
Child
Preschool
Epidemiological Monitoring
Female
Bunyaviridae
Adult
China
medicine.medical_specialty
Adolescent
Fever
030231 tropical medicine
Population
Bunyaviridae Infections
Real-Time Polymerase Chain Reaction
Microbiology
Virus
Young Adult
03 medical and health sciences
medicine
Animals
Humans
Serologic Tests
education
Aged
Infant
Newborn
Infant
biology.organism_classification
Virology
Sandfly
Microscopy
Electron
030104 developmental biology
Immunoglobulin M
Immunoglobulin G
Insect Science
Etiology
Parasitology
Severe fever with thrombocytopenia syndrome virus
Zdroj: Ticks and Tick-borne Diseases. 10:454-461
ISSN: 1877-959X
DOI: 10.1016/j.ttbdis.2018.11.011
Popis: This study reports the etiological identification, clinical diagnosis, and the results of the local epidemiological surveillance of the first case of severe fever with thrombocytopenia syndrome virus (SFTSV) infection in 2014 in Hunan Province, China. The infected patient was isolated and closely monitored. The virus is a member of the Bunyaviridae sandfly family and is characterized by real-time PCR, electron microscopy, immunofluorescence, and whole-genome sequencing. We also detected IgG and IgM antibodies against SFTSV among the local human population and domestic animals in a serological surveillance. Prevalence of SFTSV-specific antibodies was monitored in the local population for two years after the identification of the first SFTS case. Approximately 5% (4/77) of the people who had direct contact with the patient were seropositive, which is significantly higher than the seropositivity of the general local population [1.57% (44/2800), P 0.05]. Furthermore, the percentage of the general population who were seropositive was higher in 2015 than in 2014 (χ2 = 7.481, P = 0.006). The epidemiological investigation found that the SFTSV is epidemic in goats, cattle, and chickens in Hunan Province. The risk of infection of domestic animals can be minimized by feeding in pens rather than allowing foraging.
Databáze: OpenAIRE
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