The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2
| Autor: | Fabián Suárez, Alfonso Cabezón, Alexandre Blanco-González, Uxía Veleiro, Rebeca García-Fandiño, Pablo F. Garrido, Martín Calvelo, Ángel Piñeiro, Daniel Conde |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
Battle Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) media_common.quotation_subject Pneumonia Viral Pharmaceutical Science 02 engineering and technology Large range EPIC 030226 pharmacology & pharmacy Article Excipients 03 medical and health sciences Betacoronavirus 0302 clinical medicine Drug Stability Rings Blood Coagulation Pandemics media_common ComputingMethodologies_COMPUTERGRAPHICS Literature Cyclodextrins Drug Carriers business.industry SARS-CoV-2 COVID-19 Viral Vaccines 021001 nanoscience & nanotechnology Nanostructures Coronavirus 0210 nano-technology business Coronavirus Infections |
| Zdroj: | International Journal of Pharmaceutics |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2020.119689 |
| Popis: | Graphical abstract A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ∼1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. “One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them.” J. R. R. Tolkien |
| Databáze: | OpenAIRE |
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