The effect of caffeine on working memory load-related brain activation in middle-aged males

Autor: Elisabeth A. T. Evers, Jan Snel, Dick J. Veltman, Jelle Jolles, Renate H. M. de Groot, Antoon J. M. Ligtenberg, Elissa B. Klaassen, Enno C. I. Veerman
Přispěvatelé: Promovendi MHN, Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience, Educational Neuroscience, LEARN!, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, LEARN! - Brain, learning and development, Psychiatry, NCA - Neurobiology of mental health, Orale Biochemie (OII, ACTA), RS-Research Line Learning and Cognition (part of CO program), Oral Biochemistry
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Aging
Thalamus/metabolism
Coffee
Saliva/metabolism
chemistry.chemical_compound
Thalamus
Attention
Nootropic Agents
Neuropharmacology
caffeine
Netherlands
dorsolateral prefrontal cortex
Cross-Over Studies
Nootropic Agents/administration & dosage
fMRI
Middle Aged
Magnetic Resonance Imaging
Caffeine/Administration
medicine.anatomical_structure
Performance-Enhancing Substances/administration & dosage
Prefrontal Cortex/growth & development
Dorsolateral prefrontal cortex
Caffeine
Psychology
Memory
short-term
Cognitive psychology
Adult
Brain activation
Central Nervous System Stimulants/administration & dosage
Prefrontal Cortex
Performance-Enhancing Substances
Workload
working memory
Cellular and Molecular Neuroscience
Double-Blind Method
SDG 3 - Good Health and Well-being
Memory
thalamus
medicine
Humans
Saliva
Pharmacology
Aging/Metabolism
Working memory
chemistry
Coffee/adverse effects
short-term
Central Nervous System Stimulants
Neuroscience
Zdroj: Neuropharmacology, 64, 160-167. Elsevier Science
Neuropharmacology, 64, 160-167. Elsevier Limited
Klaassen, E B, de Groot, R H M, Evers, E A T, Snel, J, Veerman, E C I, Ligtenberg, A J M, Jolles, J & Veltman, D J 2013, ' The effect of caffeine on working memory load-related brain activation in middle-aged males ', Neuropharmacology, vol. 64, pp. 160-167 . https://doi.org/10.1016/j.neuropharm.2012.06.026
Neuropharmacology, 64, 160-167. Elsevier
Klaassen, E B, de Groot, R H M, Evers, E A T, Snel, J, Veerman, E C I, Ligtenberg, A J M & Jolles, J 2013, ' The effect of caffeine on working memory load-related brain activation in middle-aged males ', Neuropharmacology, vol. 64, pp. 160-167 . https://doi.org/10.1016/j.neuropharm.2012.06.026
Neuropharmacology, 64, 160-167. Pergamon Press Ltd.
Klaassen, E B, De Groot, R, Evers, E A T, Snel, J, Veerman, E C I, Ligtenberg, A J M, Jolles, J & Veltman, D J 2013, ' The effect of caffeine on working memory load-­related brain activation in middle-­aged males ', Neuropharmacology, vol. 64, pp. 160-167 . https://doi.org/10.1016/j.neuropharm.2012.06.026
ISSN: 0028-3908
1873-7064
DOI: 10.1016/j.neuropharm.2012.06.026
Popis: Caffeine is commonly consumed in an effort to enhance cognitive performance. However, little is known about the usefulness of caffeine with regard to memory enhancement, with previous studies showing inconsistent effects on memory performance. We aimed to determine the effect of caffeine on working memory (WM) load-related activation during encoding, maintenance and retrieval phases of a WM maintenance task using functional magnetic resonance imaging (fMRI). 20 healthy, male, habitual caffeine consumers aged 40-61 years were administered 100 mg of caffeine in a double-blind placebo-controlled crossover design. Participants were scanned in a non-withdrawn state following a workday during which caffeinated products were consumed according to individual normal use (range = 145-595 mg). Acute caffeine administration was associated with increased load-related activation compared to placebo in the left and right dorsolateral prefrontal cortex during WM encoding, but decreased load-related activation in the left thalamus during WM maintenance. These findings are indicative of an effect of caffeine on the fronto-parietal network involved in the top-down cognitive control of WM processes during encoding and an effect on the prefrontal cortico-thalamic loop involved in the interaction between arousal and the top-down control of attention during maintenance. Therefore, the effects of caffeine on WM may be attributed to both a direct effect of caffeine on WM processes, as well as an indirect effect on WM via arousal modulation. Behavioural and fMRI results were more consistent with a detrimental effect of caffeine on WM at higher levels of WM load, than caffeine-related WM enhancement. This article is part of a Special Issue entitled 'Cognitive Enhancers'. © 2012 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: