Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

Autor: Vilma Tapia, Gustavo F. Gonzales
Rok vydání: 2013
Předmět:
Male
obesity
creatinine blood level
Physiology
kidney disease
cholesterol blood level
hyperuricemia
chemistry.chemical_compound
Hemoglobins
high density lipoprotein cholesterol
Drug Discovery
middle aged
Medicine
Hyperuricemia
glucose
kidney function
pathophysiology
purl.org/pe-repo/ocde/ford#3.01.08 [https]
adult
Altitude
creatinine
arterial blood pressure
General Medicine
gamma-Glutamyltransferase
Middle Aged
biological marker
aged
female
Biochemistry
gamma glutamyltransferase
liver function
γ-glutamyltransferase
Hypertension
blood sampling
Biological Markers
Female
Kidney Diseases
triacylglycerol
arterial pressure
alkaline phosphatase
uric acid blood level
Adult
medicine.medical_specialty
venous blood
alanine aminotransferase
Renal function
Article
alkaline phosphatase blood level
uric acid
blood
Internal medicine
high altitude
Humans
purl.org/pe-repo/ocde/ford#3.01.05 [https]
human
Obesity
Aged
Dyslipidemias
Pharmacology
Creatinine
hemoglobin blood level
business.industry
dyslipidemia
nutritional and metabolic diseases
hemoglobin
Overweight
medicine.disease
triacylglycerol blood level
Uric Acid
Endocrinology
glucose blood level
chemistry
Hyperglycemia
Uric acid
Liver function
Hemoglobin
business
gamma glutamyl transferase blood level
metabolism
Dyslipidemia
alanine aminotransferase blood level
Biomarkers
Blood sampling
Zdroj: Journal of basic and clinical physiology and pharmacology. 26(1)
ISSN: 2191-0286
Popis: Currently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, and lipidic, hepatic and kidney markers.The present study was performed in 487 subjects aged 30–75 years living at 4100 m of altitude. A venous blood sample was drawn from each subject to measure hemoglobin, glucose, and lipid levels and markers of liver and kidney function. Quartiles for serum γGT and uric acid were calculated and associated with different physiological variables. A p-value Serum γGT values were higher in men (38.35± 2.54 IU/L) than in women (30.33±1.76 IU/L) (pAt high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.
Databáze: OpenAIRE