Radiotherapy of glioblastoma multiforme
Autor: | Oliver Lang, Erhard Liebermeister, Marie-Luise Sautter-Bihl, Jürgen Liesegang |
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Rok vydání: | 1998 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Stereotactic surgery medicine.medical_treatment Urology Central nervous system disease Quality of life Humans Medicine Radiology Nuclear Medicine and imaging Radiation treatment planning Survival rate Aged Brain Neoplasms business.industry Middle Aged medicine.disease Acute toxicity Survival Rate Radiation therapy Oncology Feasibility Studies Female Radiotherapy Adjuvant Dose Fractionation Radiation Glioblastoma business Nuclear medicine Follow-Up Studies |
Zdroj: | Strahlentherapie und Onkologie. 174:629-632 |
ISSN: | 1439-099X 0179-7158 |
Popis: | With regard to the poor prognosis of patients with glioblastoma multiforme, the aspect of life quality with a minimal treatment time becomes essential. The purpose of the present study is to evaluate whether the results of a radiotherapy schedule using increased single fractions applied over a shortened treatment time is feasible without compromising treatment efficiency or providing more side effects than a conventionally fractionated treatment.A total of 38 patients (f = 21, m = 17, mean age 58 years) with histologically proven glioblastoma multiforme were irradiated after (partial) resection (n = 29) or stereotactic surgery (n = 9) with single doses of 3.5 Gy (ICRU) 5 fractions a week up to a total dose of 42 Gy following individual treatment planning.Median survival was 45.7 weeks, survival rate after 6 months was 80.9% and decreased to 34.2% after 12 months. Radiotherapy was tolerated without any important acute toxicity or any late side effects during the follow-up period.The increase of the dose per fraction using a fraction size of 3.5 Gy enhanced neither acute nor late toxicity. The survival rate compared well to those described in the literature. Thus the shortened treatment schedule seems as efficient as conventional radiotherapy. Moreover, it seems preferable with regard to quality of life. |
Databáze: | OpenAIRE |
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