7-Aminoquinolines. A novel class of agents active against herpes viruses
| Autor: | Sandra H. Smith, John C. Drach, J. H. Burckhalter, Charles Shipman, Mohamed Nasr |
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| Rok vydání: | 1988 |
| Předmět: |
Chemical Phenomena
Cell Survival Stereochemistry Virus Replication medicine.disease_cause Antiviral Agents Cell Line Structure-Activity Relationship Viral Proteins Drug Discovery medicine Protein biosynthesis Simplexvirus Structure–activity relationship Aminoquinolines Cytotoxicity Bicyclic molecule Chemistry Biological activity DNA Molecular biology Herpes simplex virus Cell culture Protein Biosynthesis Molecular Medicine |
| Zdroj: | Journal of Medicinal Chemistry. 31:1347-1351 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 micrograms/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis. |
| Databáze: | OpenAIRE |
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