Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States
| Autor: | Edward A. Shipton, Elspeth E. Shipton |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Vitamin D deficiency Vitamin d supplementation Supplementation business.industry Incidence (epidemiology) Pain medicine Chronic pain Review medicine.disease Gastroenterology vitamin D deficiency Anesthesiology and Pain Medicine Clinical evidence Internal medicine Vitamin D and neurology Physical therapy medicine In patient Neurology (clinical) Chronic Pain Pain Processes business |
| Zdroj: | Pain and Therapy |
| ISSN: | 2193-651X 2193-8237 |
| DOI: | 10.1007/s40122-015-0036-8 |
| Popis: | Introduction A number of studies suggest a link between low levels of 25-hydroxy vitamin D and incidence of acute and chronic pain. Clinical studies of vitamin D supplementation in patients with known vitamin D deficiency have shown mixed results in improving pain scores. Methods In this article, vitamin D deficiency risk factors are observed and adequate levels of 25-hydroxy vitamin D defined. Clinical supplementation with vitamin D is explored, including the schedules used in published clinical trials. Evidence of the effectiveness of vitamin D supplementation for the treatment of chronic pain conditions from double-blind randomized controlled trials (RCTs) is examined. Results The scientific evidence for vitamin D as a treatment option for chronic pain is limited due to lack of RCTs. It cannot be stated conclusively that vitamin D deficiency is directly linked to the etiology or maintenance of chronic pain states. Conclusion There remains a growing body of both clinical and laboratory evidence pointing to a potential relationship between low levels of 25-hydroxy vitamin D and a variety of chronic pain states. More focused research involving large RCTs is necessary. Electronic supplementary material The online version of this article (doi:10.1007/s40122-015-0036-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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