Adult Reserve Stem Cells and Their Potential for Tissue Engineering

Autor: Nicholas L. Henson, Sayaka Tamura-Ninomiya, Brian W. Tobin, Amy Kirincich, Henry E. Young, John A. Hudson, Kurt Ericson, Patrick Vourc'h, Frank P. Bowyer, Amar Parikh, Timothy A. Steele, Angela J. Thompson, Laura J. Bland, T. J. Lin, Jaime Groom, Catherine Moreau, Asa C. Black, Michael J. Yost, Roy D. Russ, Takayuki Asahara, Haruchika Masuda, Mohammad El-Kalay, Louis Terracio, Marina Romero-Ramos, Kristina C. Hawkins, Kristina Detmer, Cécile Duplàa, Lisa Blake, Michael N. Horst, Douglas C. Hixson, Marie-Françoise Chesselet, Julie A. Floyd, Robert A. Bray
Rok vydání: 2004
Předmět:
Embryo
Nonmammalian
Myocardial Infarction
Stem cells
Embryoid body
Neurodegenerative
Pluripotent
Biochemistry
Induced pluripotent stem cell
Telomerase
Cellular Senescence
Mammals
Induced stem cells
Diabetes
Hematopoietic Stem Cell Transplantation
Cell Differentiation
Neurodegenerative Diseases
General Medicine
Cell biology
DNA-Binding Proteins
Endothelial stem cell
Infarction
Connective Tissue
Antigens
Surface
Myogenin
Stem cell
Germ Layers
Adult stem cell
Adult
Pluripotent Stem Cells
Mesenchymal
Biophysics
Urodela
Biology
Bone and Bones
Diabetes Mellitus
Animals
Humans
Regeneration
Cell Lineage
Progenitor cell
Muscle
Skeletal
Embyonic
Tissue Engineering
Extremities
Genetic Therapy
Cell Biology
Embryo
Mammalian
Rats
Immunology
Cattle
Octamer Transcription Factor-3
Transcription Factors
Stem cell lineage database
Zdroj: Young, H E, Duplaa, C, Romero-Ramos, M, Chesselet, M F, Vourc'h, P, Yost, M J, Ericson, K, Terracio, L, Asahara, T, Masuda, H, Tamura-Ninomiya, S, Detmer, K, Bray, R A, Steele, T A, Hixson, D, El-Kalay, M, Tobin, B W, Russ, R D, Horst, M N, Floyd, J A, Henson, N L, Hawkins, K C, Groom, J, Parikh, A, Blake, L, Bland, L J, Thompson, A J, Kirincich, A, Moreau, C, Hudson, J, Bowyer, F P, Lin, T J & Black, A C 2004, ' Adult reserve stem cells and their potential for tissue engineering ', Cell Biochemistry and Biophysics, vol. 40, no. 1, pp. 1-80 . https://doi.org/10.1385/CBB:40:1:1
ISSN: 1085-9195
DOI: 10.1385/cbb:40:1:1
Popis: Tissue restoration is the process whereby multiple damaged cell types are replaced to restore the histoarchitecture and function to the tissue. Several theories have been proposed to explain the phenomenon of tissue restoration in amphibians and in animals belonging to higher orders. These theories include dedifferentiation of damaged tissues, transdifferentiation of lineage-committed progenitor cells, and activation of reserve precursor cells. Studies by Young et al. and others demonstrated that connective tissue compartments throughout postnatal individuals contain reserve precursor cells. Subsequent repetitive single cell-cloning and cell-sorting studies revealed that these reserve precursor cells consisted of multiple populations of cells, including tissue-specific progenitor cells, germ-layer lineage stem cells, and pluripotent stem cells. Tissue-specific progenitor cells display various capacities for differentiation, ranging from unipotency (forming a single cell type) to multipotency (forming multiple cell types). However, all progenitor cells demonstrate a finite life span of 50 to 70 population doublings before programmed cell senescence and cell death occurs. Germ-layer lineage stem cells can form a wider range of cell types than a progenitor cell. An individual germ-layer lineage stem cell can form all cells types within its respective germ-layer lineage (i.e., ectoderm, mesoderm, or endoderm). Pluripotent stem cells can form a wider range of cell types than a single germ-layer lineage stem cell. A single pluripotent stem cell can form cells belonging to all three germ layer lineages. Both germ-layer lineage stem cells and pluripotent stem cells exhibit extended capabilities for self-renewal, far surpassing the limited life span of progenitor cells (50-70 population doublings). The authors propose that the activation of quiescent tissue-specific progenitor cells, germ-layer lineage stem cells, and/or pluripotent stem cells may be a potential explanation, along with dedifferentiation and transdifferentiation, for the process of tissue restoration. Several model systems are currently being investigated to determine the possibilities of using these adult quiescent reserve precursor cells for tissue engineering.
Databáze: OpenAIRE
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