Orthotopic Liver Transplantation for Etanercept-Induced Acute Hepatic Failure; a case report
| Autor: | Farid Azmoudeh-Ardalan, Dorsay Sadeghian, Simin Dashti-Khavidaki, Nasir Fakhar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population Case Report Autoimmunity Liver transplantation medicine.disease_cause Gastroenterology Etanercept Hepatitis 03 medical and health sciences 0302 clinical medicine Internal medicine Pathology medicine RB1-214 education 030203 arthritis & rheumatology Ankylosing spondylitis education.field_of_study Hepatic failure business.industry medicine.disease 030211 gastroenterology & hepatology Tumor necrosis factor alpha business Infiltration (medical) medicine.drug |
| Zdroj: | Iranian Journal of Pathology Iranian Journal of Pathology, Vol 15, Iss 4, Pp 338-341 (2020) |
| ISSN: | 2345-3656 |
| DOI: | 10.30699/ijp.2020.117000.2269 |
| Popis: | Occurrence of hepatotoxicity following prescription of etanercept, a tumor necrosis factor-alpha (TNF-α) antagonist, is a relatively well-known issue. On the other hand, acute hepatic failure which could lead to liver transplantation is extremely rare to the best of our knowledge, and there is no previously published case in the literature. In this article, we presented a case of acute liver failure followed by liver transplantaion, in a 32- year old man with a previous history of ankylosing spondylitis after etanercept usage. On pathologic examination of the explanted liver of the patient, extensive confluent necrosis in all liver segments with prominent infiltration of a mixed population of inflammatory cells in portal tracts was noticed. In conclusion, close follow-up of patients who are receiving etanercept is crucial, since its liver complications could be severe enough to subject the patients for liver transplantation. |
| Databáze: | OpenAIRE |
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