Cocaine sensitivity in roman high and low avoidance rats is modulated by sex and gonadal hormone status
| Autor: | Margaret Haney, Pierre Morme`de, Nathalie Castanon, Michel Le Moal, M Cador |
|---|---|
| Přispěvatelé: | Psychobiologie des comportements adaptatifs, Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors [SDV]Life Sciences [q-bio] Motor Activity Open field Rats Mutant Strains 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cocaine Internal medicine Abuse liability medicine Avoidance Learning Weaning Animals Castration Gonadal Steroid Hormones Molecular Biology Sensitization 030304 developmental biology 0303 health sciences Sex Characteristics General Neuroscience Rats Sexual dimorphism Endocrinology medicine.anatomical_structure chemistry Female Neurology (clinical) Psychology 030217 neurology & neurosurgery Gonadal hormones Injections Intraperitoneal Developmental Biology Hormone |
| Zdroj: | Brain Research Brain Research, Elsevier, 1994, pp.179-185. ⟨10.1016/0006-8993(94)91651-9⟩ |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(94)91651-9⟩ |
| Popis: | International audience; Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hormone levels, in rats with a genetically distinct locomotor response to novelty: Roman Low Avoidance rats (RLA) freeze while Roman High Avoidance rats (RHA) remain motorically active. Ninety-six male and female RHA and RLA rats were gonadectomized (GDX) just after weaning or as adults, or left gonadally intact. Each rat received a total of 9 injections of cocaine hydrocholoride (10 mg/kg, IP), at 3–4-day intervals for 5 weeks. Locomotor activity was measured after each injection, and stereotypies were rated 1×/week. Open field behavior (10 min) and plasma corticosterone were measured 2 weeks after the final injection. Overall, the RHA line was more sensitive to (1) cocaine's stereotypic effects, and (2) the influence of ovarian hormones on the cocaine's acute and sensitizing effects on locomotor activity. Therefore, genetic background not only determines cocaine sensitivity, but also the influence of gonadal hormones on locomotor activity. These interactions are relevant when considering the genetic contribution to abuse liability. |
| Databáze: | OpenAIRE |
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