Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts
| Autor: | Judy Ly, Daniel Pearce, Anddre Valdivia, Tommy Saing, Hicret Islamoglu, Parveen Hussain, Leslie Gonzalez, Vishwanath Venketaraman, Cesar Ochoa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult CD4-Positive T-Lymphocytes Male medicine.medical_specialty medicine.medical_treatment T cell Immunology HIV Infections Pathogenesis Biology 03 medical and health sciences chemistry.chemical_compound Interferon-gamma 0302 clinical medicine Immune system Interferon Transforming Growth Factor beta Virology Internal medicine medicine Humans Interferon gamma glutathione Aged redox homeostasis Interleukins Interleukin HIV Glutathione Transforming growth factor beta Middle Aged cytokines CD4 Lymphocyte Count AIDS 030104 developmental biology Infectious Diseases Endocrinology Cytokine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis biology.protein Female medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | HIV infects and destroys CD4+ T cells leading to a compromised immune system. In a double-blinded study, a group of HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 were given either an empty liposomal supplement or a liposomal glutathione (L-GSH) supplement to take over a 3-month period. Baseline measurements in HIV-positive subjects show a significant decrease in levels of interleukin (IL)-12, IL-2, and interferon (IFN)-γ, along with a substantial increase in the levels of IL-6, IL-10, transforming growth factor (TGF)-β, and free radicals, compared to healthy individuals. Supplementation of HIV-positive subjects with L-GSH for 3 months resulted in a notable increase in the levels of IL-12, IL-2, and IFN-γ, with a concomitant decrease in the levels of IL-6, IL-10, and free radicals, and stabilization in the levels of TGF-β, IL-1, and IL-17, compared to their placebo counterparts. Levels of free radicals in CD4+ T cells stabilized, while GSH levels increased in the treatment group. Those in the placebo group showed no significant difference throughout the study. In summary, supplementation with L-GSH in HIV-infected individuals with CD4+ T cell counts below 350 cells/mm3 can help restore redox homeostasis and cytokine balance, therefore aiding the immune system to control opportunistic infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|