Cardiotonic effects of anthopleurin-A (AP-A), A polypeptide from a sea anemone, in dogs with a coronary artery stenosis
| Autor: | David C. Warltier, Harold F. Hardman, Shoji Shibata, Garrett J. Gross |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Inotrope Mean arterial pressure medicine.medical_specialty Cardiotonic Agents Blood Pressure Coronary Disease Anterior Descending Coronary Artery Dogs Heart Rate Coronary Circulation Internal medicine Heart rate medicine Animals Anthopleurin Pharmacology biology business.industry Fissipedia Blood flow biology.organism_classification Myocardial Contraction Endocrinology Blood pressure Cardiology Intercellular Signaling Peptides and Proteins Female Peptides business |
| Zdroj: | European Journal of Pharmacology. 110:271-276 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(85)90223-7 |
| Popis: | The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5-5.0 micrograms/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 +/- 100 to 2650 +/- 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 +/- 1.7 to 13.7 +/- 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure. |
| Databáze: | OpenAIRE |
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