Serum N-glycan profile shift during human ageing
| Autor: | Cuiying Chitty Chen, Sylviane Dewaele, Peter Paul De Deyn, Koos Jaspers, Florence Debacq-Chainiaux, Ingrid van der Pluijm, Michel Poulain, Jan H.J. Hoeijmakers, Olivier Toussaint, Sebastiaan Engelborghs, Youri Glupczynski, Claude Libert, Claudio Franceschi, Valerie Vanhooren |
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| Přispěvatelé: | Molecular Genetics, Clinical sciences, Neurology, Department for Molecular Biomedical Research, Department of Biomedical Molecular Biology, Universiteit Gent = Ghent University [Belgium] (UGENT), Reference Center for Biological Markers of Memory Disorders, University of Namur - FUNDP / URBC 61, GéDAP - Faculté des sciences économiques, Cliniques universitaires UCL de Mont-Godinne 5530 Yvoir, Dept. Experimental Pathology, Vanhooren V., Dewaele S., Libert C., Engelborghs S., De Deyn P.P., Toussaint O., Debacq-Chainiaux F., Poulain M., Glupczynski Y., Franceschi C., Jaspers K., van der Pluijm I., Hoeijmakers J., Chen C.C. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Aging
Physiology NGA2F Glycomics/instrumentation Disease Biochemistry Cockayne syndrome 0302 clinical medicine Endocrinology Young adult Glycomics Medicine(all) Aged 80 and over 0303 health sciences NA2F Middle Aged 3. Good health Cockayne Syndrome/blood Dementia/blood Biomarker (medicine) CS Adult Electrophoresis Aging/blood Biology Sensitivity and Specificity 03 medical and health sciences Young Adult SDG 3 - Good Health and Well-being Polysaccharides Genetics medicine Dementia Humans Electrophoresis/instrumentation Cockayne Syndrome Molecular Biology 030304 developmental biology Aged age-related disease Surrogate endpoint Cell Biology Biomarker Sequence Analysis DNA medicine.disease DSA-FACE Ageing ageing Immunology Polysaccharides/blood N-glycan profile Sequence Analysis DNA/instrumentation Human medicine Body mass index 030217 neurology & neurosurgery Biomarkers/blood Biomarkers |
| Zdroj: | Experimental Gerontology, 45(10), 738-743. Elsevier Inc. Experimental gerontology Experimental Gerontology; Vol 45 Experimental Gerontology Experimental Gerontology, Elsevier, 2010, 45 (10), pp.738. ⟨10.1016/j.exger.2010.08.009⟩ |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2010.08.009⟩ |
| Popis: | Biomarkers indicating biological age are of significant interest for prevention, diagnosis and monitoring (and the treatment) of age-related diseases. We previously reported an alteration of serum N-glycan profile in old humans using "DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis" (DSA-FACE). To validate the shift in serum N-glycan profile during ageing, we studied serum N-glycan profiles in different age groups of healthy volunteers, patients with dementia, and patients with Cockayne syndrome, a genetic DNA repair disorder involving neurodegeneration and premature ageing. We found that the log of the ratio of two glycans (NGA2F and NA2F), named GlycoAgeTest, remained steady up to the age of 40. years and thereafter gradually increased to reach its highest level in nonagenarians. Patients with dementia or Cockayne syndrome had a higher GlycoAgeTest level than age-matched healthy individuals. We thus demonstrate that the value of GlycoAgeTest is better than chronological age for estimating the physiological age of a human individual, and that it could be used as an ageing biomarker for healthy humans. Our data indicate that the GlycoAgeTest could be used as a non-invasive surrogate marker for general health, for forecasting disease progression during ageing, and for monitoring the efficacy of anti-ageing food compounds. © 2010 Elsevier Inc. |
| Databáze: | OpenAIRE |
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