Carotid artery wall thickness in patients with obstructive sleep apnea syndrome
| Autor: | Roberto Baruffaldi, Mauro Silvestrini, Barbara Rizzato, Marina Diomedi, Alberto Bianconi, Fabio Placidi |
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| Rok vydání: | 2002 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty genetic structures Polysomnography Posture Central nervous system disease Risk Factors Internal medicine Respiratory disturbance index medicine Humans Oximetry Ultrasonography Doppler Color Stroke Advanced and Specialized Nursing Sleep disorder Sleep Apnea Obstructive medicine.diagnostic_test business.industry Vascular disease Sleep apnea Middle Aged medicine.disease Surgery Obstructive sleep apnea Carotid Arteries nervous system Cardiology Neurology (clinical) Disease Susceptibility Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 33(7) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose — Epidemiological studies have suggested a pathophysiological link between sleep apnea syndrome and cerebrovascular diseases. The mechanism by which sleep disturbance can affect the predisposition to developing stroke is not clear. The aim of this study was to investigate whether patients with obstructive sleep apnea syndrome have an increase in atherosclerosis indicators at the carotid artery level. Methods — We included 23 male patients with severe obstructive sleep apnea syndrome (respiratory disturbance index >30). Intima-media thickness and the presence of steno-occlusive lesions in the common carotid arteries were investigated with B-mode high-resolution ultrasonography. Results of the ultrasonographic examination were compared with those of a group of 23 subjects without obstructive sleep apnea syndrome who were matched for age and comorbid factors. Results — The intima-media thickness of the common carotid arteries of patients with obstructive sleep apnea syndrome was significantly higher ( P Conclusions — Results of the present study show that carotid wall thickness is increased in patients with severe sleep apnea syndrome. There is strong evidence that an increase in the thickness of the carotid artery wall is a valid marker of the risk of stroke. For this reason, our finding seems to further strengthen the hypothesis that patients with obstructive sleep apnea syndrome are at risk of developing cerebrovascular diseases regardless of the association with other vascular risk factors. |
| Databáze: | OpenAIRE |
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