Manganese(I)-Catalyzed C−H Activation: The Key Role of a 7-Membered Manganacycle in H-Transfer and Reductive Elimination
| Autor: | Kate M. Appleby, Adrian C. Whitwood, Joshua T. W. Bray, L. Anders Hammarback, Nasiru P. Yahaya, Jason M. Lynam, Conrad Wagner, Jonathan S. Ward, Jessica Milani, Simon B. Duckett, Ian J. S. Fairlamb, Natalie E. Pridmore, Magdalene Teh, Erik Troschke |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_element
Manganese 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis Reductive elimination chemistry.chemical_compound Organic chemistry 010405 organic chemistry Communication Substrate (chemistry) Regioselectivity General Chemistry sustainability Communications 0104 chemical sciences chemistry manganese functionalization Surface modification Pyridinium C−H Activation |
| Zdroj: | Angewandte Chemie (International Ed. in English) |
| ISSN: | 1433-7851 |
| Popis: | Manganese‐catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered MnI intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnI by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry. |
| Databáze: | OpenAIRE |
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