Collaborative health and enforcement operations on the quality of antimalarials and antibiotics in southeast Asia
| Autor: | Michael D. Green, Thitikornkovit Dumrong, Aline Plançon, Yen Hui Lau, Dana M. Hostetler, Suon Nara, Paul N. Newton, Ruth Lee Choo Ai, Mam Boravann, Sourisak Sounvoravong, Chin-Chin Lim, Nurjaya Bangsawan, Facundo M. Fernández, Min Yong Low, Yuk-Lin Yong |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class International Cooperation 030231 tropical medicine Antibiotics Pharmacology Corrections Southeast asia 03 medical and health sciences chemistry.chemical_compound Antimalarials 0302 clinical medicine Virology Environmental health medicine 030212 general & internal medicine Enforcement Drug packaging Asia Southeastern Drug Packaging business.industry Public health Field Studies and Innovations Legislation Drug 3. Good health Counterfeit Anti-Bacterial Agents Infectious Diseases chemistry Artesunate Counterfeit Drugs Parasitology business |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 |
| Popis: | Counterfeit (or falsified) and substandard medicines pose a major public health risk. We describe the findings of Operation Storm I and II conducted in 2008–2009 to combat counterfeit medicines through partnership between national customs, Drug Regulatory Agencies (DRAs), and police in Cambodia, Indonesia, Laos, Myanmar, Singapore, Thailand, and Vietnam. Samples were obtained from seizures and market surveillance by national DRAs. Laboratory analysis using spectroscopic and chromatographic techniques and examination of packaging were performed. Ninety-three suspect antibiotics and 95 antimalarial samples were collected. Of the 93 antibiotics, 29 (31%) had % active pharmaceutical ingredient content (%API) < 85% or > 115% (including one counterfeit). Of the 95 antimalarials, 30 (32%) had %API < 85 > 115% API (including one counterfeit). A significant minority of samples, antimalarials (13%) and antibiotics (15%), were collected in plastic bags with minimal or no labeling. Of 20 ampicillin samples, 13 (65%) contained < 85% API (with one counterfeit containing additional amoxicillin). Of 34 oral artesunate samples, 7 (21%) contained %API out of the 85–115% range. Coordinated and synergistic partnership adopted by the participating countries, International Criminal Police Organization (INTERPOL), World Health Organization (WHO), and laboratories facilitated a platform for discussions and intelligence sharing, helping to improve each participating country's capacity to combat poor-quality medicines. |
| Databáze: | OpenAIRE |
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